HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C28 (Q7Z3Y7)
Keratin, type I cytoskeletal 28 (Cytokeratin-28) (CK-28) (Keratin-25D) (K25D) (Keratin-28) (K28) (Type I inner root sheath-specific keratin-K25irs4)
Gene: KRT28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 464
+	Hs
		359290 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C14_HUMAN (84-450): 7.84e-143: 418: 56.40
+	Hs
		409054 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C17_HUMAN (79-444): 5.22e-141: 412: 57.10
+	Hs
		408990 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C13_HUMAN (72-412): 2.41e-139: 409: 55.43
+	Hs
		49549 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		A1A4E9_HUMAN (72-412): 2.52e-139: 409: 55.13
+	Hs
		444534 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		K1C17_HUMAN (79-444): 5.22e-141: 412: 57.10
+	Hs
		409094 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C24_HUMAN (81-432): 4.79e-125: 375: 60.48
+	Hs
		408981 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C16_HUMAN (82-408): 1.11e-118: 357: 60.86
+	Hs
		359288 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		K1C14_HUMAN (84-450): 7.84e-143: 418: 56.40
+	Hs
		408980 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C19_HUMAN (80-396): 8.65e-115: 344: 57.73
+	Hs
		409000 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C15_HUMAN (85-396): 6.09e-114: 344: 60.26
+	Hs
		409082 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H1_HUMAN (37-416): 3.12e-110: 333: 42.00
+	Hs
		409116 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C40_HUMAN (4-420): 1.31e-109: 332: 38.28
+	Hs
		409134 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C28_HUMAN (1-464): 7.64e-85: 270: 100.00
+	Hs
		409072 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H2_HUMAN (5-401): 9.06e-78: 251: 41.29
+	Hs
		280770 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT36_HUMAN (5-408): 1.44e-75: 245: 44.44
+	Hs
		409184 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT35_HUMAN (1-401): 1.3e-75: 245: 42.75
+	Hs
		409136 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C26_HUMAN (1-463): 1.78e-74: 243: 67.02
+	Hs
		409135 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C27_HUMAN (1-460): 3.71e-71: 234: 76.09
+	Hs
		409137 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C25_HUMAN (1-451): 3.72e-70: 231: 72.31
+	Hs
		280768 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		KRT36_HUMAN (5-408): 1.44e-75: 245: 44.44