Protein: GAB1
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)

Gene: GAB1
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q13480

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987613

GRB2
Growth factor receptor-bound protein 2

20

20

Small-scale

0.991

High

363235

EGFR
Epidermal growth factor receptor

12

20

Small-scale

0.977

High

292833

GRAP2
GRB2-related adapter protein 2

7

20

Small-scale

0.963

High

855866

CRKL
Crk-like protein

4

20

Small-scale

0.886

High

619053

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

4

Small-scale

0.870

High

472056

MET
Hepatocyte growth factor receptor

3

20

Small-scale

0.827

High

1106516

ALK
ALK tyrosine kinase receptor

3

20

Small-scale

0.827

High

440063

LCK
Tyrosine-protein kinase Lck

2

20

High-throughput

0.789

High

463507

LYN
Tyrosine-protein kinase Lyn

2

20

High-throughput

0.789

High

855612

CRK
Adapter molecule crk

2

20

High-throughput

0.789

High

635716

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.777

High

1053660

PTN11
Tyrosine-protein phosphatase non-receptor type 11

17

16

Small-scale

0.764

High

699736

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

11

20

Small-scale

0.760

High

375489

RASK
GTPase KRas

2

20

High-throughput

0.754

High

411881

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

541470

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.754

High

710225

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

463955

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.737

High

1106487

MARK2
Serine/threonine-protein kinase MARK2

1

1

Small-scale

0.724

High

1106500

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

Small-scale

0.724

High

1049145

RON
Macrophage-stimulating protein receptor

1

20

Small-scale

0.713

High

222077

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.692

High

456105

FES
Tyrosine-protein kinase Fes/Fps

1

20

High-throughput

0.692

High

463085

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.692

High

473414

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.692

High

557285

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.692

High

584536

VAV
Proto-oncogene vav

1

19

High-throughput

0.692

High

593987

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.692

High

599288

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

4

High-throughput

0.692

High

840880

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.692

High

849162

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.692

High

902834

BLK
Tyrosine-protein kinase Blk

1

20

High-throughput

0.692

High

913647

VAV2
Guanine nucleotide exchange factor VAV2

1

17

High-throughput

0.692

High

1054106

BTK
Tyrosine-protein kinase BTK

1

20

High-throughput

0.692

High

1065081

ITK
Tyrosine-protein kinase ITK/TSK

1

20

High-throughput

0.692

High

1098881

SLAP1
Src-like-adapter

1

20

High-throughput

0.692

High

1106474

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.692

High

1106507

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.692

High

1106510

TENS1
Tensin-1

1

6

High-throughput

0.692

High

1106514

VAV3
Guanine nucleotide exchange factor VAV3

1

20

High-throughput

0.692

High

941779

ARL4C
ADP-ribosylation factor-like protein 4C

1

10

High-throughput

0.691

High

711340

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.674

High

1106515

STAP1
Signal-transducing adaptor protein 1

1

0

High-throughput

0.657

High

410818

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.647

High

658699

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

728218

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.647

High

720211

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.646

High

1106492

PARD3
Partitioning defective 3 homolog

3

20

Small-scale

0.640

High

712860

CASP1
Caspase-1

3

0

High-throughput

0.638

High

1041046

CAV1
Caveolin-1

3

3

High-throughput

0.633

High

1106518

GAB2
GRB2-associated-binding protein 2

1

14

Small-scale

0.621

High

126580

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

373913

RASN
GTPase NRas

1

20

High-throughput

0.618

High

374572

RASH
GTPase HRas

1

20

High-throughput

0.618

High

465512

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

484130

PGFRB
Platelet-derived growth factor receptor beta

1

14

High-throughput

0.618

High

601275

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

710827

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

711885

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

835663

KPCI
Protein kinase C iota type

1

6

Small-scale

0.618

High

891149

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.618

High

891519

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.618

High

932066

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

936317

AFAD
Afadin

1

16

High-throughput

0.618

High

953429

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962020

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

976248

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

977985

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988340

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015418

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1106472

GAB1
GRB2-associated-binding protein 1

1

13

High-throughput

0.618

High

1106475

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.618

High

1106476

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1106477

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1106480

AR13B
ADP-ribosylation factor-like protein 13B

1

7

High-throughput

0.618

High

1106488

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1106493

FRS2
Fibroblast growth factor receptor substrate 2

1

2

Small-scale

0.618

High

1106506

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1106509

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

868683

LEG7
Galectin-7

2

1

High-throughput

0.611

High

990188

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1106496

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.602

High

582777

EZRI
Ezrin

2

14

High-throughput

0.584

High

614686

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

8

High-throughput

0.584

High

1106260

ROCK1
Rho-associated protein kinase 1

1

6

Small-scale

0.575

High

882659

EFTU
Elongation factor Tu, mitochondrial

2

2

High-throughput

0.574

High

550264

PABP1
Polyadenylate-binding protein 1

2

4

High-throughput

0.571

High

577741

PLAK
Junction plakoglobin

2

8

High-throughput

0.571

High

587647

DESP
Desmoplakin

2

11

High-throughput

0.571

High

987011

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

4

High-throughput

0.571

High

1036719

DSG1
Desmoglein-1

2

9

High-throughput

0.571

High

1090055

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

2

10

Small-scale

0.571

High

1106504

PABP3
Polyadenylate-binding protein 3

2

4

High-throughput

0.571

High

1106513

CALL5
Calmodulin-like protein 5

2

2

High-throughput

0.571

High

341047

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.553

High

648504

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

931845

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

1106484

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.553

High

1106517

TF2AY
TFIIA-alpha and beta-like factor

1

0

High-throughput

0.549

High

136383

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.536

High

155938

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.536

High

156039

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.536

High

164859

SH21B
SH2 domain-containing protein 1B

1

20

High-throughput

0.536

High

187347

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

4

High-throughput

0.536

High

294858

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.536

High

1106482

TENS3
Tensin-3

1

6

High-throughput

0.536

High

1106490

TENS4
Tensin-4

1

11

High-throughput

0.536

High

1106494

BLNK
B-cell linker protein

1

19

High-throughput

0.536

High

1106495

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.536

High

1106498

HSH2D
Hematopoietic SH2 domain-containing protein

1

20

High-throughput

0.536

High

1106512

SH22A
SH2 domain-containing protein 2A

1

20

High-throughput

0.536

High

878451

PAXI
Paxillin

1

6

Small-scale

0.536

High

1106489

CUL9
Cullin-9

1

1

High-throughput

0.536

High

841720

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

1

High-throughput

0.521

High

1106503

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

8

High-throughput

0.521

High

67665

RHG32
Rho GTPase-activating protein 32

1

13

Small-scale

0.515

High

1099666

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1106519

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

862104

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.501

High

1106501

SH23A
SH2 domain-containing protein 3A

1

20

High-throughput

0.489

High

1106502

TRI15
E3 ubiquitin-protein ligase TRIM15

1

2

Small-scale

0.481

High

226022

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

299179

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

347680

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

475961

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

9

Small-scale

0.479

High

556062

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

603967

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

690980

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

715571

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

729807

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730567

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

845630

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

966279

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971489

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

991838

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

1004050

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.479

High

1049262

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1058005

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.479

High

1087100

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1106473

CUL4B
Cullin-4B

1

4

High-throughput

0.479

High

1106478

OCLN
Occludin

1

3

High-throughput

0.479

High

1106499

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1106505

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.479

High

1106508

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1106511

E41LA
Band 4.1-like protein 4A

1

11

High-throughput

0.479

High

1032463

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

Small-scale

0.458

High

471743

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

8

High-throughput

0.445

High

658823

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

6

High-throughput

0.445

High

659022

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

5

High-throughput

0.445

High

839001

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

7

High-throughput

0.445

High

848996

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

10

High-throughput

0.445

High

1050788

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

18

High-throughput

0.445

High

189552

STX7
Syntaxin-7

1

6

High-throughput

0.437

High

327253

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.437

High

642851

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

1106483

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1106485

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1106491

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1106497

CK052
Uncharacterized protein C11orf52

1

4

High-throughput

0.437

High

877420

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

7

Small-scale

0.408

High

1106479

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

5

High-throughput

0.407

High

731811

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

3

Small-scale

0.373

High

1106481

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

2

0

High-throughput

0.298

High

1106486

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

469480

SYPH
Synaptophysin

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025