Interactor 1: HMGCL (P35914)
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
Gene: HMGCL

Interactor 2: HMGC2 (Q8TB92)
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL)
Gene: HMGCLL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HMGL-like~HMGL-like
Common GO terms GO:0004419 - hydroxymethylglutaryl-CoA lyase activity
GO:0005829 - cytosol
GO:0006552 - L-leucine catabolic process
GO:0046872 - metal ion binding
GO:0046951 - ketone body biosynthetic process
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 325
Hs

1 370
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc
+ Sp
+ Sc
+ Ss
+ Sc
+ Sc
+ Sc
+ Hs

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Last updated: 15 Jul 2024