HitPredict

Interactor 1: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 16530705, 20224550, 21130043
Identification Methods coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, ig~I-set, I-set~Ig_2, ig~ig, Ig_2~ig, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, VEGFR-2_TMD~VEGFR-2_TMD
Common GO terms GO:0001525 - angiogenesis
GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001945 - lymph vessel development
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
and 20 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1363
Hs

1 1356
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Last updated: 15 Jul 2024