HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.880

Property	Details
Experiments	10749680, 12214271, 9790910
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1356 Hs			1 582
+	Hs
		666023 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Hs
		729650 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		GRB10_HUMAN (8-575): 3.58e-39: 153: 11.61
+	Hs
		522825 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Hs
		557625 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Hs
		729636 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Dm
		112229 M9MRE1_DROME (31-1354): 0: 608: 21.17		Q9V3C8_DROME (119-580): 3.81e-82: 265: 35.05
+	Dm
		186281 Q8IPG1_DROME (31-1354): 0: 609: 21.44		O18683_DROME (458-580): 3.41e-36: 143: 30.95
+	Dm
		112212 M9MRE1_DROME (31-1354): 0: 608: 21.17		CSW_DROME (482-578): 4.65e-14: 77.6: 21.78
+	Mm
		403421 RET_MOUSE (809-1201): 1.5e-77: 281: 41.01		SRC_MOUSE (341-573): 3.33e-38: 149: 15.98
+	Mm
		643062 RET_MOUSE (809-1201): 1.5e-77: 281: 41.01		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		433221 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		452338 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Hs
		208979 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		NCK2_HUMAN (271-578): 3.22e-39: 149: 13.29
+	Hs
		145969 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SH2B2_HUMAN (299-581): 3.55e-37: 148: 18.62
+	Hs
		557172 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		SHF_HUMAN (360-578): 3.1e-35: 139: 21.05
+	Hs
		452344 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Hs
		557041 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		452361 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		557215 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01
+	Hs
		557088 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07