HitPredict

Interactor 1: VGFR1 (P35969)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
Gene: Flt1

Interactor 2: PK3CG (Q9JHG7)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: Pik3cg

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21665146
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0006935 - chemotaxis GO:0016477 - cell migration
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1333 Mm			1 1102
+	Dm
		112213 M9MRE1_DROME (26-1254): 0: 740: 25.66		P91634_DROME (29-1090): 0: 911: 29.47
+	Hs
		572639 VGFR1_HUMAN (21-1332): 0: 959: 81.49		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		787220 CNTN1_HUMAN (1-772): 1.31e-63: 238: 13.30		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		557059 PGFRA_HUMAN (1-415): 4.52e-27: 121: 12.31		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		607905 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		426990 CSF1R_HUMAN (467-855): 8.22e-16: 85: 13.12		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		499240 KIT_HUMAN (2-233): 5.36e-12: 72.7: 13.23		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Mm
		403539 KIT_MOUSE (2-268): 2.79e-12: 73.9: 11.04		PK3CA_MOUSE (23-1093): 0: 979: 32.32
+	Hs
		135765 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		P3C2B_HUMAN (235-1095): 0: 765: 29.95
+	Hs
		135760 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		P3C2B_HUMAN (235-1095): 0: 765: 29.95
+	Hs
		609327 FGFR3_HUMAN (2-234): 1.37e-33: 142: 10.39		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		738220 FLT3_HUMAN (14-571): 7.83e-23: 108: 13.79		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		452416 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		ATR_HUMAN (698-1043): 3.2e-88: 315: 18.33