HitPredict

Interactor 1: GRIK3 (B1AS29)
Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7)
Gene: GRIK3

Interactor 2: GRIK4 (Q8BMF5)
Glutamate receptor ionotropic, kainate 4 (GluK4) (Glutamate receptor KA-1) (KA1)
Gene: GRIK4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12954862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANF_receptor~ANF_receptor, ANF_receptor~Lig_chan, ANF_receptor~Lig_chan-Glu_bd, Lig_chan~Lig_chan, Lig_chan~Lig_chan-Glu_bd, Lig_chan-Glu_bd~Lig_chan-Glu_bd
Common GO terms	GO:0099507 - ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 919 Mm			1 956
+	Hs
		1092410 GRIK3_HUMAN (1-919): 0: 981: 99.02		GRIK4_HUMAN (1-956): 0: 900: 97.91
+	Hs
		1092401 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIK4_HUMAN (1-956): 0: 900: 97.91
+	Mm
		73013 GRIK3_MOUSE (1-919): 0: 981: 100.00		GRIK2_MOUSE (1-897): 0: 847: 42.51
+	Rn
		838433 GRIK3_RAT (1-919): 0: 980: 99.46		GRIK2_RAT (1-897): 0: 848: 42.62
+	Hs
		811288 GRIK3_HUMAN (1-919): 0: 981: 99.02		GRIK1_HUMAN (3-890): 0: 833: 40.35
+	Rn
		652696 GRIK3_RAT (1-919): 0: 980: 99.46		GRIK1_RAT (3-862): 0: 824: 41.47
+	Hs
		1092409 GRIK3_HUMAN (1-919): 0: 981: 99.02		GRIK3_HUMAN (6-898): 0: 820: 40.84
+	Rn
		838542 GRIK3_RAT (1-919): 0: 980: 99.46		GRIK3_RAT (6-908): 0: 817: 40.61
+	Hs
		1092411 GRIK3_HUMAN (1-919): 0: 981: 99.02		GRIK5_HUMAN (1-933): 0: 800: 69.06
+	Hs
		1092399 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIK2_HUMAN (1-897): 0: 851: 42.73
+	Rn
		838432 GRIK2_RAT (8-909): 0: 929: 79.31		GRIK2_RAT (1-897): 0: 848: 42.62
+	Rn
		838543 GRIK3_RAT (1-919): 0: 980: 99.46		GRIK5_RAT (1-933): 0: 794: 68.61
+	Hs
		811287 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIK1_HUMAN (3-890): 0: 833: 40.35
+	Rn
		652695 GRIK2_RAT (8-909): 0: 929: 79.31		GRIK1_RAT (3-862): 0: 824: 41.47
+	Hs
		1092402 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIK5_HUMAN (1-933): 0: 800: 69.06
+	Rn
		838436 GRIK2_RAT (8-909): 0: 929: 79.31		GRIK5_RAT (1-933): 0: 794: 68.61
+	Hs
		838452 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIA1_HUMAN (1-906): 0: 787: 33.44
+	Hs
		838490 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRIA2_HUMAN (8-839): 0: 747: 34.54
+	Hs
		215877 GRIK2_HUMAN (1-909): 0: 929: 78.71		GRID2_HUMAN (7-954): 0: 608: 23.73