HitPredict

Interactor 1: CEAM8 (P31997)
Cell adhesion molecule CEACAM8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Carcinoembryonic antigen-related cell adhesion molecule 8) (CEA cell adhesion molecule 8) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Gene: CEACAM8

Interactor 2: CEAM6 (P40199)
Cell adhesion molecule CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) (CEA cell adhesion molecule 6) (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)
Gene: CEACAM6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.825

The method score is based on:

Property Details
Experiments 21982860, 26483485
Identification Methods pull down, isothermal titration calorimetry, x-ray crystallography, protein array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ig_2~Ig_2, Ig_2~Ig_3, Ig_2~V-set, Ig_3~Ig_3, Ig_3~V-set, V-set~V-set
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007157 - heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0009986 - cell surface
GO:0035577 - azurophil granule membrane
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 349
Hs

1 344
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Service provided by Combinatics, Japan

Last updated: 11Aug2025