HitPredict

Interactor 1: SWD2 (P36104)
COMPASS component SWD2 (Complex proteins associated with SET1 protein SWD2) (Set1C component SWD2)
Gene: SWD2

Interactor 2: PFS2 (P42841)
Polyadenylation factor subunit 2
Gene: PFS2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	11742990, 12819204, 16554755, 16429126, 21179020
Identification Methods	coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 329 Sc			1 465
+	Sp
		1358082 YIQ4_SCHPO (11-329): 2.81e-100: 300: 29.43		PFS2_SCHPO (15-463): 3.07e-95: 298: 34.80
+	Hs
		1281292 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		FBXW7_HUMAN (162-460): 3.24e-68: 232: 18.63
+	Hs
		1346954 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		NLE1_HUMAN (168-460): 1.4e-68: 228: 14.78
+	Hs
		197071 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		PRP4_HUMAN (205-464): 1.43e-47: 173: 14.29
+	Sp
		999842 TUP12_SCHPO (104-328): 1.17e-49: 176: 17.60		TUP11_SCHPO (244-460): 3.08e-41: 157: 15.42
+	Hs
		921751 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		GBB2_HUMAN (193-448): 1.18e-32: 128: 17.69
+	Hs
		196910 PRP4_HUMAN (115-328): 4.42e-39: 146: 11.21		PRP4_HUMAN (205-464): 1.43e-47: 173: 14.29
+	Sc
		630844 NLE1_YEAST (2-228): 2.98e-53: 184: 10.82		NLE1_YEAST (302-464): 2.54e-32: 130: 10.35
+	Hs
		903418 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30
+	Hs
		1103007 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		SMU1_HUMAN (65-377): 4.02e-17: 85.5: 21.18
+	Hs
		1240442 POC1A_HUMAN (146-329): 6.01e-35: 133: 14.67		POC1B_HUMAN (248-461): 9.49e-45: 164: 13.70
+	Dm
		1358845 WDS_DROME (3-232): 4.95e-61: 200: 11.81		WDS_DROME (344-461): 1.16e-17: 86: 10.57
+	Hs
		903551 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30
+	Hs
		903428 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30
+	Hs
		792949 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30
+	Mm
		925836 LIS1_MOUSE (2-184): 1.63e-52: 179: 11.82		LIS1_MOUSE (344-460): 2.08e-16: 82.9: 13.12
+	Hs
		792935 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		LIS1_HUMAN (344-460): 2.38e-16: 82.6: 13.12
+	Hs
		903349 WDR5B_HUMAN (146-328): 9.18e-44: 154: 14.21		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30
+	Hs
		196984 PRP4_HUMAN (115-328): 4.42e-39: 146: 11.21		WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30