Protein: ITCH
E3 ubiquitin-protein ligase Itchy (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Itchy homolog)

Gene: ITCH
Organism: Mus musculus
Interactions: 33
UniProt ID: Q8C863

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032088

NOTC1
Neurogenic locus notch homolog protein 1

2

15

Small-scale

0.834

High

999865

TRAF6
TNF receptor-associated factor 6

4

20

Small-scale

0.694

High

1190389

TAXB1
Tax1-binding protein 1 homolog

3

8

Small-scale

0.650

High

811920

TRAF2
TNF receptor-associated factor 2

2

13

Small-scale

0.621

High

767027

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

Small-scale

0.618

High

1221636

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

12

Small-scale

0.601

High

1281913

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

2

Small-scale

0.601

High

867722

GLI1
Zinc finger protein GLI1

2

4

Small-scale

0.584

High

1298169

NFIP1
NEDD4 family-interacting protein 1

2

17

Small-scale

0.584

High

1223900

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

9

Small-scale

0.561

High

1224193

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.536

High

1298173

RNF11
RING finger protein 11

1

15

Small-scale

0.536

High

205508

CFLAR
CASP8 and FADD-like apoptosis regulator

1

3

Small-scale

0.527

High

313424

KLF10
Krueppel-like factor 10

1

10

Small-scale

0.515

High

1298168

SHOT1
Shootin-1

1

1

Small-scale

0.512

High

59773

LRAD3
Low-density lipoprotein receptor class A domain-containing protein 3

1

7

Small-scale

0.479

High

147547

DPYL2
Dihydropyrimidinase-related protein 2

1

9

Small-scale

0.479

High

432098

JUN
Transcription factor Jun

1

5

Small-scale

0.479

High

482137

JUNB
Transcription factor JunB

1

5

Small-scale

0.479

High

902807

RORG
Nuclear receptor ROR-gamma

1

8

Small-scale

0.479

High

986930

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

1000494

CXCR4
C-X-C chemokine receptor type 4

1

7

Small-scale

0.479

High

1223850

RBP1
RalA-binding protein 1

1

6

Small-scale

0.479

High

1296511

WBP1L
WW domain binding protein 1-like

1

10

Small-scale

0.479

High

1297153

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.479

High

1298167

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

4

Small-scale

0.479

High

1298170

MAVS
Mitochondrial antiviral-signaling protein

1

11

Small-scale

0.479

High

1298171

ARRB2
Beta-arrestin-2

1

6

Small-scale

0.479

High

1298172

IFM3
Interferon-induced transmembrane protein 3

1

3

Small-scale

0.479

High

1298174

SUFU
Suppressor of fused homolog

1

1

Small-scale

0.479

High

777966

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

204392

MCPT9
Mast cell protease 9

1

4

Small-scale

0.437

High

1024978

MCPTX
Mast cell protease-like protein

1

4

Small-scale

0.437

High


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Last updated: 11Aug2025