HitPredict

Interactor 1: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	16554755, 37968396, 31848235, 22940862, 16429126, 14759368
Identification Methods	affinity chromatography technology, cross-linking study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT_2~MitMem_reg, JAB~PC_rep
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 945 Sc			1 338
+	Hs
		906587 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	Hs
		695 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	Dm
		684557 PSMD1_DROME (1-927): 0: 990: 36.04		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Hs
		138283 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	Sp
		268020 RPN2_SCHPO (3-938): 0: 1002: 41.56		RPN11_SCHPO (1-263): 3.36e-61: 199: 19.11
+	Dm
		1463621 PSMD1_DROME (1-927): 0: 990: 36.04		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Hs
		906512 PSMD2_HUMAN (9-770): 0: 760: 17.31		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	At
		1422013 PSD2A_ARATH (9-770): 0: 669: 17.76		PSD7B_ARATH (6-311): 1.9e-100: 300: 49.03
+	At
		200894 PSD2A_ARATH (9-770): 0: 669: 17.76		PSD7A_ARATH (6-308): 6.58e-100: 298: 49.18
+	Dm
		684572 Q9VW54_DROME (13-770): 0: 651: 17.61		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Sp
		267634 RPN1_SCHPO (9-770): 0: 621: 18.33		RPN8_SCHPO (5-321): 6.07e-99: 296: 50.78
+	Hs
		138092 PSMD2_HUMAN (9-770): 0: 760: 17.31		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	At
		1442983 PSD2A_ARATH (9-770): 0: 669: 17.76		PSDE_ARATH (3-263): 1.26e-46: 161: 17.65
+	Sp
		836442 RPN1_SCHPO (9-770): 0: 621: 18.33		RPN11_SCHPO (1-263): 3.36e-61: 199: 19.11
+	Dm
		1463632 Q9VW54_DROME (13-770): 0: 651: 17.61		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Sc
		803707 RPN1_YEAST (9-573): 1.14e-134: 430: 17.33		RPN8_YEAST (1-338): 6.54e-119: 348: 100.00