HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0048488 - synaptic vesicle endocytosis GO:0098794 - postsynapse
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 937
+	Hs
		742260 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		742154 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		119926 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17
+	Hs
		742275 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		AP3B2_HUMAN (16-594): 2.55e-174: 537: 28.71