HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: CDK18 (Q07002)
Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3)
Gene: CDK18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 474
+	Hs
		625186 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK2_HUMAN (141-436): 1.07e-146: 422: 52.69
+	Hs
		758188 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK3_HUMAN (141-443): 4.63e-144: 416: 49.84
+	Hs
		300629 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK14_HUMAN (3-465): 8.83e-137: 403: 44.85
+	Hs
		414796 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK1_HUMAN (141-430): 6.84e-137: 397: 51.54
+	Mm
		763415 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK2_MOUSE (141-436): 8.08e-138: 401: 45.09
+	Hs
		758190 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK5_HUMAN (141-431): 4.4e-133: 387: 55.29
+	Mm
		509470 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK1_MOUSE (141-430): 1.76e-135: 393: 51.20
+	Hs
		804108 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK17_HUMAN (6-474): 1.13e-147: 433: 62.26
+	Hs
		804107 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK16_HUMAN (3-465): 1.22e-147: 432: 61.52
+	Xl
		1153623 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q6IRQ7_XENLA (141-435): 3.1e-146: 421: 52.19
+	Xl
		616668 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK2_XENLA (141-435): 5.23e-146: 420: 51.85
+	Hs
		625207 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK2_HUMAN (141-436): 1.07e-146: 422: 52.69
+	Hs
		804104 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK3_HUMAN (141-443): 4.63e-144: 416: 49.84
+	Rn
		139842 O08769_RAT (7-156): 2.11e-38: 131: 25.83		CDK2_RAT (141-436): 2.76e-147: 423: 52.35
+	Xl
		724512 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK1A_XENLA (141-434): 1.95e-137: 399: 49.83
+	Hs
		300630 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK14_HUMAN (3-465): 8.83e-137: 403: 44.85
+	Hs
		414811 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK1_HUMAN (141-430): 6.84e-137: 397: 51.54
+	Mm
		803840 CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27		CDK2_MOUSE (141-436): 8.08e-138: 401: 45.09
+	Hs
		804083 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK7_HUMAN (138-470): 1.68e-134: 393: 35.59
+	Hs
		804106 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK5_HUMAN (141-431): 4.4e-133: 387: 55.29