HitPredict

Interactor 1: DYN1 (P39053)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: Dnm1

Interactor 2: SH3K1 (Q8R550)
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
Gene: Sh3kbp1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20551902
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0017124 - SH3 domain binding GO:0030139 - endocytic vesicle GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 867 Mm			1 709
+	Hs
		983399 DYN1_HUMAN (1-845): 0: 1051: 99.65		SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15
+	Mm
		760481 DYN2_MOUSE (1-845): 0: 986: 78.28		SH3K1_MOUSE (1-709): 3.26e-141: 432: 100.00
+	Hs
		840786 DYN2_HUMAN (1-845): 0: 985: 77.93		SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15
+	Mm
		223006 DYN1_MOUSE (1-867): 0: 1087: 100.00		NCK2_MOUSE (103-445): 1.71e-28: 120: 13.39
+	Mm
		760469 DYN1_MOUSE (1-867): 0: 1087: 100.00		ITSN1_MOUSE (1-131): 1.6e-16: 86.3: 24.43
+	Hs
		209034 DYN1_HUMAN (1-845): 0: 1051: 99.65		NCK2_HUMAN (103-446): 5.13e-28: 118: 13.64
+	Hs
		557664 DYN1_HUMAN (1-845): 0: 1051: 99.65		NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10
+	Hs
		983379 DYN1_HUMAN (1-845): 0: 1051: 99.65		ITSN1_HUMAN (205-465): 2.83e-17: 88.6: 15.81
+	Hs
		983387 DYN1_HUMAN (1-845): 0: 1051: 99.65		DNMBP_HUMAN (47-369): 1.61e-14: 80: 12.28
+	Rn
		599413 DYN1_RAT (1-845): 0: 1043: 98.34		ITSN1_RAT (1-131): 2.11e-16: 85.9: 24.43
+	Rn
		599402 DYN1_RAT (1-845): 0: 1043: 98.34		GRB2_RAT (318-390): 7.64e-15: 76.1: 32.43
+	Hs
		983392 DYN1_HUMAN (1-845): 0: 1051: 99.65		NOSTN_HUMAN (289-373): 1.11e-10: 66.6: 40.00
+	Rn
		192739 DYN1_RAT (1-845): 0: 1043: 98.34		SRBS2_RAT (276-507): 1.2e-10: 67: 19.51
+	Hs
		840719 DYN2_HUMAN (1-845): 0: 985: 77.93		SH319_HUMAN (5-373): 3.57e-22: 103: 17.34
+	Hs
		840702 DYN2_HUMAN (1-845): 0: 985: 77.93		ITSN1_HUMAN (205-465): 2.83e-17: 88.6: 15.81
+	Mm
		760488 DYN2_MOUSE (1-845): 0: 986: 78.28		ITSN1_MOUSE (1-131): 1.6e-16: 86.3: 24.43
+	Hs
		840840 DYN2_HUMAN (1-845): 0: 985: 77.93		ITSN2_HUMAN (247-409): 9.74e-17: 87.1: 19.02
+	Hs
		840739 DYN2_HUMAN (1-845): 0: 985: 77.93		DNMBP_HUMAN (47-369): 1.61e-14: 80: 12.28
+	Rn
		192740 DYN2_RAT (1-845): 0: 986: 78.16		SRBS2_RAT (276-507): 1.2e-10: 67: 19.51
+	Hs
		840747 DYN2_HUMAN (1-845): 0: 985: 77.93		SH3R1_HUMAN (275-636): 2.93e-09: 62.4: 10.75