HitPredict

Interactor 1: GRIK1 (P39086)
Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
Gene: GRIK1

Interactor 2: PICK1 (Q9NRD5)
PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
Gene: PICK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	12597860, 35914814
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042734 - presynaptic membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 918 Hs			1 415
+	Rn
		611607 GRIK1_RAT (1-891): 0: 919: 94.39		PICK1_RAT (1-415): 0: 597: 96.39
+	Rn
		786686 GRIK2_RAT (12-909): 0: 881: 76.64		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		1022367 GRIK2_HUMAN (6-909): 0: 885: 76.46		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Hs
		786710 GRIA1_HUMAN (14-913): 0: 776: 37.08		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		585217 GRIA4_RAT (20-918): 0: 766: 35.79		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		816226 GRIA4_HUMAN (20-918): 0: 765: 35.79		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Hs
		786764 GRIA3_HUMAN (1-904): 0: 760: 35.88		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		585195 GRIA3_RAT (7-904): 0: 750: 36.01		PICK1_RAT (1-415): 0: 597: 96.39
+	Rn
		585182 GRIA2_RAT (3-904): 0: 739: 35.42		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		786746 GRIA2_HUMAN (3-904): 0: 743: 35.53		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Mm
		620964 GRIA2_MOUSE (3-904): 0: 740: 35.42		PICK1_MOUSE (1-415): 0: 584: 94.47