Protein: RON
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]

Gene: RON, MST1R
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q04912

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005011 - macrophage colony-stimulating factor receptor activity
GO:0005524 - ATP binding
GO:0005773 - vacuole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689919

HGFL
Hepatocyte growth factor-like protein

3

20

Small-scale

0.771

High

987563

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

690930

1433T
14-3-3 protein theta

2

20

Small-scale

0.743

High

1049145

GAB1
GRB2-associated-binding protein 1

1

20

Small-scale

0.713

High

168399

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.691

High

919904

PLK1
Serine/threonine-protein kinase PLK1

1

13

High-throughput

0.691

High

990127

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.691

High

1049208

BTNL2
Butyrophilin-like protein 2

1

20

High-throughput

0.691

High

175359

PLXB2
Plexin-B2

1

20

Small-scale

0.665

High

208127

PLXB1
Plexin-B1

1

19

Small-scale

0.665

High

1049209

PLXB3
Plexin-B3

1

20

Small-scale

0.665

High

728185

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

651289

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.646

High

410790

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

1049156

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.621

High

1049157

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.618

High

461387

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

573442

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

619031

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.618

High

619217

EPOR
Erythropoietin receptor

1

20

Small-scale

0.618

High

711318

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

729766

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.618

High

730528

1433S
14-3-3 protein sigma

1

20

Small-scale

0.618

High

858634

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.618

High

862813

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

High-throughput

0.618

High

911915

JAK3
Tyrosine-protein kinase JAK3

1

19

High-throughput

0.618

High

966220

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

971428

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.618

High

1049137

RON
Macrophage-stimulating protein receptor

1

20

Small-scale

0.618

High

1049138

1433F
14-3-3 protein eta

1

20

Small-scale

0.618

High

1049173

SYNE1
Nesprin-1

1

20

High-throughput

0.618

High

1049179

TITIN
Titin

1

8

High-throughput

0.618

High

1049202

WNK1
Serine/threonine-protein kinase WNK1

1

20

High-throughput

0.618

High

967678

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

Small-scale

0.578

High

1049211

CHIP
E3 ubiquitin-protein ligase CHIP

1

12

Small-scale

0.561

High

1049168

LRC49
Leucine-rich repeat-containing protein 49

1

20

High-throughput

0.553

High

1049146

PTC1
Protein patched homolog 1

1

4

High-throughput

0.536

High

1049180

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.536

High

1049187

T106A
Transmembrane protein 106A

1

8

High-throughput

0.536

High

1049188

ASIC4
Acid-sensing ion channel 4

1

4

High-throughput

0.536

High

133491

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

464691

CXB1
Gap junction beta-1 protein

1

19

Small-scale

0.501

High

191438

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

543187

UBL4A
Ubiquitin-like protein 4A

1

9

High-throughput

0.489

High

548001

PSPC
Surfactant protein C

1

8

High-throughput

0.489

High

567837

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.489

High

856653

BAG6
Large proline-rich protein BAG6

1

18

High-throughput

0.489

High

1049164

BRID5
BRICHOS domain-containing protein 5

1

7

High-throughput

0.489

High

1049199

KLK15
Kallikrein-15

1

13

High-throughput

0.489

High

1049204

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.489

High

218088

TGON2
Trans-Golgi network integral membrane protein 2

1

20

High-throughput

0.479

High

243609

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

3

High-throughput

0.479

High

245091

AQR
RNA helicase aquarius

1

2

High-throughput

0.479

High

280589

PR40A
Pre-mRNA-processing factor 40 homolog A

1

16

High-throughput

0.479

High

331567

KIF4A
Chromosome-associated kinesin KIF4A

1

5

High-throughput

0.479

High

447743

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.479

High

452239

PDIA1
Protein disulfide-isomerase

1

20

High-throughput

0.479

High

460506

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

High-throughput

0.479

High

487221

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

537020

HSP7C
Heat shock cognate 71 kDa protein

1

11

Small-scale

0.479

High

566642

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.479

High

612203

ARF4
ADP-ribosylation factor 4

1

19

High-throughput

0.479

High

613338

VINC
Vinculin

1

19

High-throughput

0.479

High

716177

ERP29
Endoplasmic reticulum resident protein 29

1

20

High-throughput

0.479

High

717447

PDIA3
Protein disulfide-isomerase A3

1

20

High-throughput

0.479

High

854009

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.479

High

855054

NOP2
28S rRNA

1

9

High-throughput

0.479

High

983458

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

12

High-throughput

0.479

High

995407

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.479

High

1008101

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

High-throughput

0.479

High

1049139

CALD1
Caldesmon

1

20

High-throughput

0.479

High

1049142

CKAP4
Cytoskeleton-associated protein 4

1

19

High-throughput

0.479

High

1049144

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

2

High-throughput

0.479

High

1049150

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

10

High-throughput

0.479

High

1049151

SMC1A
Structural maintenance of chromosomes protein 1A

1

12

High-throughput

0.479

High

1049155

SYK
Lysine--tRNA ligase

1

8

High-throughput

0.479

High

1049166

DHX29
ATP-dependent RNA helicase DHX29

1

5

High-throughput

0.479

High

1049167

LYRIC
Protein LYRIC

1

2

High-throughput

0.479

High

1049169

DYH10
Dynein axonemal heavy chain 10

1

10

High-throughput

0.479

High

1049181

DDX1
ATP-dependent RNA helicase DDX1

1

2

High-throughput

0.479

High

1049185

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.479

High

1049203

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

1

High-throughput

0.479

High

1049206

VAPA
Vesicle-associated membrane protein-associated protein A

1

13

High-throughput

0.479

High

1049210

COR1C
Coronin-1C

1

3

High-throughput

0.479

High

1049212

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.479

High

1049214

SMC3
Structural maintenance of chromosomes protein 3

1

12

High-throughput

0.479

High

1049216

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

644496

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.458

High

849331

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

860172

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

1049159

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

0

High-throughput

0.458

High

1049162

HGNAT
Heparan-alpha-glucosaminide N-acetyltransferase

1

0

High-throughput

0.458

High

1049165

GLPK5
Glycerol kinase 5

1

0

High-throughput

0.458

High

1049175

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.458

High

1049198

PDIP3
Polymerase delta-interacting protein 3

1

5

High-throughput

0.457

High

380538

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.445

High

488777

FURIN
Furin

1

3

Small-scale

0.445

High

49311

SHOT1
Shootin-1

1

1

High-throughput

0.437

High

72983

WDR64
WD repeat-containing protein 64

1

4

High-throughput

0.437

High

85530

HNRC3
Heterogeneous nuclear ribonucleoprotein C-like 3

1

14

High-throughput

0.437

High

159615

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.437

High

182118

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.437

High

214198

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

5

High-throughput

0.437

High

290539

SURF6
Surfeit locus protein 6

1

4

High-throughput

0.437

High

354219

ZBED1
E3 SUMO-protein ligase ZBED1

1

1

High-throughput

0.437

High

426255

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.437

High

488001

DPOLA
DNA polymerase alpha catalytic subunit

1

1

High-throughput

0.437

High

635126

ICAL
Calpastatin

1

4

High-throughput

0.437

High

751316

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

1

High-throughput

0.437

High

770159

RL22
Large ribosomal subunit protein eL22

1

2

High-throughput

0.437

High

786555

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

Small-scale

0.437

High

840042

CASP3
Caspase-3

1

1

High-throughput

0.437

High

858897

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.437

High

859580

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.437

High

868500

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.437

High

880290

RL34
Large ribosomal subunit protein eL34

1

1

High-throughput

0.437

High

880528

LMAN1
Protein ERGIC-53

1

7

High-throughput

0.437

High

895538

SERPH
Serpin H1

1

8

High-throughput

0.437

High

960402

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.437

High

985624

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.437

High

1015973

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.437

High

1049141

EXOS9
Exosome complex component RRP45

1

3

High-throughput

0.437

High

1049143

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

9

High-throughput

0.437

High

1049147

NOG2
Nucleolar GTP-binding protein 2

1

6

High-throughput

0.437

High

1049148

BOP1
Ribosome biogenesis protein BOP1

1

3

High-throughput

0.437

High

1049149

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

15

High-throughput

0.437

High

1049152

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

13

High-throughput

0.437

High

1049153

LBR
Delta(14)-sterol reductase LBR

1

2

High-throughput

0.437

High

1049154

CND2
Condensin complex subunit 2

1

2

High-throughput

0.437

High

1049160

GLE1
mRNA export factor GLE1

1

6

High-throughput

0.437

High

1049170

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

15

High-throughput

0.437

High

1049171

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

2

High-throughput

0.437

High

1049172

TXND5
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.437

High

1049174

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

10

High-throughput

0.437

High

1049176

BRX1
Ribosome biogenesis protein BRX1 homolog

1

6

High-throughput

0.437

High

1049177

NOC3L
Nucleolar complex protein 3 homolog

1

1

High-throughput

0.437

High

1049182

H1X
Histone H1.10

1

1

High-throughput

0.437

High

1049183

GCN1
Stalled ribosome sensor GCN1

1

13

High-throughput

0.437

High

1049184

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.437

High

1049186

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

20

High-throughput

0.437

High

1049190

ZN512
Zinc finger protein 512

1

8

High-throughput

0.437

High

1049192

DAA10
Dynein axonemal assembly factor 10

1

1

High-throughput

0.437

High

1049195

NP1L4
Nucleosome assembly protein 1-like 4

1

2

High-throughput

0.437

High

1049196

EBP2
Probable rRNA-processing protein EBP2

1

2

High-throughput

0.437

High

1049197

GNL3
Guanine nucleotide-binding protein-like 3

1

6

High-throughput

0.437

High

1049200

TMX1
Thioredoxin-related transmembrane protein 1

1

20

High-throughput

0.437

High

1049201

UN45A
Protein unc-45 homolog A

1

14

High-throughput

0.437

High

1049205

FBX6
F-box only protein 6

1

20

High-throughput

0.437

High

1049213

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

1049215

SF3B6
Splicing factor 3B subunit 6

1

5

High-throughput

0.437

High

1049217

COPG1
Coatomer subunit gamma-1

1

11

High-throughput

0.437

High

1049218

TACC3
Transforming acidic coiled-coil-containing protein 3

1

20

High-throughput

0.437

High

1049219

PCLO
Protein piccolo

1

12

High-throughput

0.437

High

1034722

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

301023

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.249

Low

303529

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

788639

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.249

Low

842341

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.249

Low

866651

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.249

Low

963279

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.249

Low

973407

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.249

Low

984386

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.249

Low

1013745

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.249

Low

1049140

EMAL5
Echinoderm microtubule-associated protein-like 5

1

0

High-throughput

0.249

Low

1049158

TBR1
T-box brain protein 1

1

0

High-throughput

0.249

Low

1049161

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.249

Low

1049163

H3C
Histone H3.3C

1

0

High-throughput

0.249

Low

1049178

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.249

Low

1049189

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

1049191

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.249

Low

1049193

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.249

Low

1049194

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.249

Low

1049207

UXT
Protein UXT

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025