Protein: PP2BA
Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)

Gene: PP2BA, PPP3CA
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q08209

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989897

CANB1
Calcineurin subunit B type 1

17

20

Small-scale

0.988

High

1062396

CANB2
Calcineurin subunit B type 2

2

20

High-throughput

0.793

High

923657

RCAN1
Calcipressin-1

7

11

Small-scale

0.749

High

340876

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

4

13

Small-scale

0.708

High

1062368

RCAN2
Calcipressin-2

4

11

Small-scale

0.696

High

665887

AKAP5
A-kinase anchor protein 5

4

1

Small-scale

0.696

High

1062413

RCAN3
Calcipressin-3

4

11

Small-scale

0.694

High

593836

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

14

High-throughput

0.691

High

539160

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

5

High-throughput

0.667

High

1062371

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

3

14

High-throughput

0.667

High

1062391

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

3

2

High-throughput

0.667

High

1062416

SIK3
Serine/threonine-protein kinase SIK3

3

9

High-throughput

0.667

High

1062384

TENS4
Tensin-4

3

8

High-throughput

0.665

High

1062405

ARMT1
Damage-control phosphatase ARMT1

3

1

High-throughput

0.665

High

1062393

CP074
Uncharacterized protein C16orf74

5

1

High-throughput

0.660

High

891489

GSK3B
Glycogen synthase kinase-3 beta

3

18

High-throughput

0.656

High

1062380

TRI72
Tripartite motif-containing protein 72

3

2

Small-scale

0.653

High

185635

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.647

High

987581

GRB2
Growth factor receptor-bound protein 2

3

11

High-throughput

0.646

High

429780

JUN
Transcription factor Jun

2

8

Small-scale

0.629

High

1062387

PAR3L
Partitioning defective 3 homolog B

1

20

High-throughput

0.618

High

1062369

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

Small-scale

0.618

High

1062382

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

15

Small-scale

0.618

High

1062417

CSEN
Calsenilin

1

0

Small-scale

0.614

High

891138

GSK3A
Glycogen synthase kinase-3 alpha

2

18

High-throughput

0.611

High

897633

RASF2
Ras association domain-containing protein 2

2

1

High-throughput

0.611

High

699920

IP3KB
Inositol-trisphosphate 3-kinase B

2

3

High-throughput

0.606

High

883043

AMPH
Amphiphysin

2

7

High-throughput

0.606

High

1062365

U119A
Protein unc-119 homolog A

2

1

High-throughput

0.606

High

1062410

ABI2
Abl interactor 2

2

16

High-throughput

0.606

High

1062415

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

7

High-throughput

0.606

High

62114

KLRG2
Killer cell lectin-like receptor subfamily G member 2

3

2

High-throughput

0.604

High

1062383

T200A
Transmembrane protein 200A

3

2

High-throughput

0.604

High

1062409

NSMA2
Sphingomyelin phosphodiesterase 3

2

0

High-throughput

0.602

High

241498

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

522081

BCL2
Apoptosis regulator Bcl-2

2

13

Small-scale

0.584

High

516330

CALM1
Calmodulin-1

1

18

High-throughput

0.575

High

516405

CALM2
Calmodulin-2

1

18

High-throughput

0.575

High

516506

CALM3
Calmodulin-3

1

18

High-throughput

0.575

High

986367

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

Small-scale

0.575

High

947982

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.574

High

622446

ELK1
ETS domain-containing protein Elk-1

2

2

High-throughput

0.571

High

934522

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.571

High

1062364

GRB10
Growth factor receptor-bound protein 10

2

17

High-throughput

0.571

High

1062389

SH3K1
SH3 domain-containing kinase-binding protein 1

2

13

High-throughput

0.571

High

371860

MYC
Myc proto-oncogene protein

1

14

Small-scale

0.561

High

727557

SC6A4
Sodium-dependent serotonin transporter

1

2

Small-scale

0.561

High

1062394

F167A
Protein FAM167A

2

1

High-throughput

0.553

High

563679

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.552

High

648494

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.541

High

761212

RYK
Tyrosine-protein kinase RYK

1

9

High-throughput

0.541

High

1062363

PTK7
Inactive tyrosine-protein kinase 7

1

4

High-throughput

0.541

High

791334

SYUA
Alpha-synuclein

1

0

Small-scale

0.537

High

1062366

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

13

Small-scale

0.536

High

161981

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

11

High-throughput

0.536

High

443334

CDK1
Cyclin-dependent kinase 1

1

12

High-throughput

0.536

High

571597

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

996669

TBA1B
Tubulin alpha-1B chain

1

7

High-throughput

0.536

High

1062377

LBH
Protein LBH

1

2

High-throughput

0.536

High

1062388

PMEPA
Protein TMEPAI

1

2

High-throughput

0.536

High

1062397

SPT33
Spermatogenesis-associated protein 33

1

2

High-throughput

0.536

High

105818

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

954797

PSA6
Proteasome subunit alpha type-6

1

0

Small-scale

0.529

High

1062367

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

138377

ZN593
Zinc finger protein 593

1

0

High-throughput

0.513

High

1062399

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

326950

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.501

High

507877

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

1062412

KLHL3
Kelch-like protein 3

1

1

Small-scale

0.501

High

1062414

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.501

High

862636

UTRN
Utrophin

1

9

Small-scale

0.500

High

1062379

LMTK1
Serine/threonine-protein kinase LMTK1

1

19

High-throughput

0.494

High

361229

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

504687

F163B
Protein FAM163B

1

2

High-throughput

0.489

High

1062404

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

2

Small-scale

0.481

High

1062411

PLAC8
Placenta-specific gene 8 protein

1

1

High-throughput

0.481

High

1062418

CABIN
Calcineurin-binding protein cabin-1

1

10

Small-scale

0.481

High

315506

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

362264

ABL1
Tyrosine-protein kinase ABL1

1

5

High-throughput

0.479

High

404005

GCR
Glucocorticoid receptor

1

14

High-throughput

0.479

High

413705

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

487231

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

588542

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

695293

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

704520

RXRB
Retinoic acid receptor RXR-beta

1

10

High-throughput

0.479

High

728196

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

768034

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

830621

CCNF
Cyclin-F

1

13

High-throughput

0.479

High

929915

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

Small-scale

0.479

High

951638

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.479

High

1062359

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

3

Small-scale

0.479

High

1062360

TRAF3
TNF receptor-associated factor 3

1

11

Small-scale

0.479

High

1062361

TADBP
TAR DNA-binding protein 43

1

10

Small-scale

0.479

High

1062362

MK07
Mitogen-activated protein kinase 7

1

7

Small-scale

0.479

High

1062373

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1062374

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.479

High

1062376

CRTC2
CREB-regulated transcription coactivator 2

1

8

Small-scale

0.479

High

1062381

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1062386

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.479

High

1062395

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

1062401

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

1062402

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1062403

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

1062406

MYOZ1
Myozenin-1

1

1

Small-scale

0.479

High

1062407

MYOZ2
Myozenin-2

1

1

Small-scale

0.479

High

1062392

Q96EJ4
PLAC8 protein

1

1

High-throughput

0.470

High

1062385

ARL14
ADP-ribosylation factor-like protein 14

1

0

High-throughput

0.458

High

1062400

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

641581

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

9

High-throughput

0.457

High

1062408

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

404774

PRIO
Major prion protein

1

1

High-throughput

0.445

High

529696

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

1062370

LASP1
LIM and SH3 domain protein 1

1

4

Small-scale

0.445

High

1062378

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.445

High

1062419

S4A7
Sodium bicarbonate cotransporter 3

1

2

High-throughput

0.445

High

848244

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

1062375

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

960366

SMS
Somatostatin

1

0

Small-scale

0.426

High

1062398

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

886794

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

1062372

ADIPO
Adiponectin

1

4

High-throughput

0.407

High

1062390

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.407

High


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Last updated: 11Aug2025