HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: PCDG5 (Q9Y5G8)
Protocadherin gamma-A5 (PCDH-gamma-A5)
Gene: PCDHGA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 931
+	Hs
		761319 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDG6_HUMAN (1-916): 0: 1100: 76.23
+	Hs
		761321 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDGB_HUMAN (5-916): 0: 1096: 74.10
+	Hs
		761318 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDG7_HUMAN (1-916): 0: 1093: 75.35
+	Hs
		761317 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDGH_HUMAN (2-916): 0: 1062: 52.68
+	Hs
		557550 SRC_HUMAN (315-602): 1.72e-108: 338: 30.80		PCDG5_HUMAN (1-916): 0: 1134: 100.00
+	Hs
		463273 YES_HUMAN (315-602): 2.53e-108: 338: 31.14		PCDG6_HUMAN (1-916): 0: 1100: 76.23
+	Hs
		541785 FGFR1_HUMAN (137-599): 1.53e-144: 440: 27.29		PCDA8_HUMAN (24-904): 0: 965: 39.55
+	Hs
		761315 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDB2_HUMAN (12-773): 0: 620: 46.68
+	Hs
		541784 FGFR1_HUMAN (137-599): 1.53e-144: 440: 27.29		PCDB7_HUMAN (27-773): 0: 601: 46.95
+	Hs
		412885 NTRK1_HUMAN (122-607): 1.18e-128: 398: 25.65		PCDB3_HUMAN (12-773): 0: 615: 47.26
+	Hs
		463272 YES_HUMAN (315-602): 2.53e-108: 338: 31.14		PCDB3_HUMAN (12-773): 0: 615: 47.26
+	Hs
		720375 UFO_HUMAN (315-603): 3.57e-55: 203: 37.63		PCDB3_HUMAN (12-773): 0: 615: 47.26
+	Hs
		245761 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDGC_HUMAN (2-444): 7.86e-97: 327: 29.41
+	Hs
		761309 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDGK_HUMAN (2-443): 3.11e-90: 309: 26.75
+	Hs
		761316 RYK_HUMAN (1-607): 1.2e-146: 438: 100.00		PCDGL_HUMAN (2-443): 1e-87: 302: 26.70
+	Hs
		412804 NTRK1_HUMAN (122-607): 1.18e-128: 398: 25.65		PCDGK_HUMAN (2-443): 3.11e-90: 309: 26.75
+	Hs
		463260 YES_HUMAN (315-602): 2.53e-108: 338: 31.14		PCDGK_HUMAN (2-443): 3.11e-90: 309: 26.75
+	Hs
		557525 SRC_HUMAN (315-602): 1.72e-108: 338: 30.80		PCDGK_HUMAN (2-443): 3.11e-90: 309: 26.75
+	Mm
		591173 MET_MOUSE (330-593): 4.03e-59: 216: 39.47		PCDAA_MOUSE (2-372): 6.18e-62: 229: 25.07