Protein: RYK
Tyrosine-protein kinase RYK (EC 2.7.10.1)

Gene: RYK
Organism: Homo sapiens
Interactions: 200
UniProt ID: P34925

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004888 - transmembrane signaling receptor activity
GO:0005109 - frizzled binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

761231

CDC37
Hsp90 co-chaperone Cdc37

3

19

Small-scale

0.861

High

761255

AGRA3
Adhesion G protein-coupled receptor A3

3

18

Small-scale

0.861

High

761228

EPHA7
Ephrin type-A receptor 7

2

20

High-throughput

0.798

High

522601

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

20

Small-scale

0.789

High

710091

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.789

High

761197

EPHA4
Ephrin type-A receptor 4

2

20

Small-scale

0.789

High

761217

PTK7
Inactive tyrosine-protein kinase 7

2

18

Small-scale

0.789

High

761218

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

20

Small-scale

0.789

High

761246

FAT4
Protocadherin Fat 4

2

18

Small-scale

0.789

High

761271

FAT3
Protocadherin Fat 3

2

20

Small-scale

0.789

High

761284

AGRA2
Adhesion G protein-coupled receptor A2

2

20

Small-scale

0.789

High

761226

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

761244

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

4

20

Small-scale

0.696

High

472002

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.691

High

564805

NCAM1
Neural cell adhesion molecule 1

1

20

High-throughput

0.691

High

614657

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

High-throughput

0.691

High

641131

FGFR2
Fibroblast growth factor receptor 2

1

17

High-throughput

0.691

High

648440

FGFR4
Fibroblast growth factor receptor 4

1

16

High-throughput

0.691

High

658853

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

20

High-throughput

0.691

High

761190

KC1E
Casein kinase I isoform epsilon

1

15

High-throughput

0.691

High

761196

EPHB4
Ephrin type-B receptor 4

1

20

High-throughput

0.691

High

761206

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.691

High

761213

CNTN1
Contactin-1

1

12

High-throughput

0.691

High

761219

PLD1
Phospholipase D1

1

2

High-throughput

0.691

High

761227

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

20

High-throughput

0.691

High

761234

PRTG
Protogenin

1

20

High-throughput

0.691

High

761237

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

1

19

High-throughput

0.691

High

761239

SDK2
Protein sidekick-2

1

20

High-throughput

0.691

High

761250

SDK1
Protein sidekick-1

1

20

High-throughput

0.691

High

761272

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

20

High-throughput

0.691

High

761273

LRC15
Leucine-rich repeat-containing protein 15

1

20

High-throughput

0.691

High

761280

NEO1
Neogenin

1

20

High-throughput

0.691

High

761299

LRC4B
Leucine-rich repeat-containing protein 4B

1

20

High-throughput

0.691

High

761233

MICA
MHC class I polypeptide-related sequence A

3

18

High-throughput

0.667

High

239754

PCDH7
Protocadherin-7

3

20

Small-scale

0.660

High

761254

MIB1
E3 ubiquitin-protein ligase MIB1

3

19

Small-scale

0.656

High

439663

INSR
Insulin receptor

1

19

High-throughput

0.646

High

580736

PVR
Poliovirus receptor

2

18

High-throughput

0.628

High

749310

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.628

High

761248

S39A5
Zinc transporter ZIP5

2

7

High-throughput

0.628

High

761251

MILR1
Allergin-1

2

20

High-throughput

0.628

High

761262

SIGL1
SIGLEC family-like protein 1

2

2

High-throughput

0.628

High

761270

RAE1E
Retinoic acid early transcript 1E

2

20

High-throughput

0.628

High

761317

PCDGH
Protocadherin gamma-B5

2

20

High-throughput

0.618

High

296448

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

443224

CDK1
Cyclin-dependent kinase 1

1

20

Small-scale

0.618

High

691645

MK03
Mitogen-activated protein kinase 3

1

9

Small-scale

0.618

High

703456

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.618

High

710783

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

761195

EPHB3
Ephrin type-B receptor 3

1

20

Small-scale

0.618

High

761208

DYST
Dystonin

1

20

High-throughput

0.618

High

761209

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

761214

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

9

Small-scale

0.618

High

761256

MIRO2
Mitochondrial Rho GTPase 2

1

20

Small-scale

0.618

High

761258

ABI1
Abl interactor 1

1

20

Small-scale

0.618

High

761310

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

18

High-throughput

0.618

High

249034

NRP2
Neuropilin-2

2

8

Small-scale

0.611

High

299946

CBPD
Carboxypeptidase D

2

9

High-throughput

0.611

High

761241

FREM2
FRAS1-related extracellular matrix protein 2

2

14

Small-scale

0.611

High

761243

CD276
CD276 antigen

2

20

Small-scale

0.611

High

761282

CDHR1
Cadherin-related family member 1

2

20

Small-scale

0.611

High

761283

PCD16
Protocadherin-16

2

20

Small-scale

0.611

High

761292

PCDH9
Protocadherin-9

2

20

Small-scale

0.611

High

761294

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

20

Small-scale

0.611

High

761301

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

2

20

Small-scale

0.611

High

761302

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

2

20

Small-scale

0.611

High

761306

S53A1
Solute carrier family 53 member 1

2

3

High-throughput

0.611

High

761308

KDIS
Kinase D-interacting substrate of 220 kDa

2

17

High-throughput

0.611

High

761321

PCDGB
Protocadherin gamma-A11

2

19

Small-scale

0.611

High

761235

CEA21
Cell adhesion molecule CEACAM21

3

13

High-throughput

0.609

High

409283

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

15

High-throughput

0.601

High

761225

DSC3
Desmocollin-3

2

20

Small-scale

0.594

High

761184

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

761207

DSC2
Desmocollin-2

2

20

Small-scale

0.584

High

761223

DSG2
Desmoglein-2

2

20

Small-scale

0.584

High

290872

PPM1B
Protein phosphatase 1B

1

6

High-throughput

0.541

High

761212

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

9

High-throughput

0.541

High

163246

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

17

High-throughput

0.536

High

164265

NRP1
Neuropilin-1

1

8

High-throughput

0.536

High

167735

PCD17
Protocadherin-17

1

20

High-throughput

0.536

High

245761

PCDGC
Protocadherin gamma-A12

1

20

High-throughput

0.536

High

269656

PLXA2
Plexin-A2

1

20

High-throughput

0.536

High

424149

S10A8
Protein S100-A8

1

7

High-throughput

0.536

High

552471

FA5
Coagulation factor V

1

9

High-throughput

0.536

High

563306

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

582137

INGR1
Interferon gamma receptor 1

1

7

High-throughput

0.536

High

684476

CTNA2
Catenin alpha-2

1

15

High-throughput

0.536

High

749750

CADH5
Cadherin-5

1

20

High-throughput

0.536

High

761188

HSP13
Heat shock 70 kDa protein 13

1

14

High-throughput

0.536

High

761189

PTH2R
Parathyroid hormone 2 receptor

1

12

High-throughput

0.536

High

761193

BCAM
Basal cell adhesion molecule

1

20

High-throughput

0.536

High

761200

ACTA
Actin, aortic smooth muscle

1

8

High-throughput

0.536

High

761201

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

High-throughput

0.536

High

761204

EFNB1
Ephrin-B1

1

12

High-throughput

0.536

High

761211

PCDH1
Protocadherin-1

1

20

High-throughput

0.536

High

761215

ANK3
Ankyrin-3

1

12

High-throughput

0.536

High

761221

CD166
CD166 antigen

1

20

High-throughput

0.536

High

761222

DAG1
Dystroglycan 1

1

9

High-throughput

0.536

High

761230

EFNB3
Ephrin-B3

1

12

High-throughput

0.536

High

761232

MICB
MHC class I polypeptide-related sequence B

1

18

High-throughput

0.536

High

761240

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

761245

CSPG4
Chondroitin sulfate proteoglycan 4

1

14

High-throughput

0.536

High

761247

KAT3
Kynurenine--oxoglutarate transaminase 3

1

2

High-throughput

0.536

High

761252

DSG4
Desmoglein-4

1

20

High-throughput

0.536

High

761263

DCBD1
Discoidin, CUB and LCCL domain-containing protein 1

1

7

High-throughput

0.536

High

761266

NLGN2
Neuroligin-2

1

1

High-throughput

0.536

High

761268

PCD19
Protocadherin-19

1

20

High-throughput

0.536

High

761276

YLAT2
Y+L amino acid transporter 2

1

12

High-throughput

0.536

High

761279

NECT2
Nectin-2

1

20

High-throughput

0.536

High

761281

KIRR1
Kin of IRRE-like protein 1

1

14

High-throughput

0.536

High

761286

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

5

High-throughput

0.536

High

761287

PKP4
Plakophilin-4

1

20

High-throughput

0.536

High

761289

ULBP3
UL16-binding protein 3

1

20

High-throughput

0.536

High

761293

PCD18
Protocadherin-18

1

20

High-throughput

0.536

High

761298

CNNM1
Metal transporter CNNM1

1

7

High-throughput

0.536

High

761300

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

761303

PDXL2
Podocalyxin-like protein 2

1

6

High-throughput

0.536

High

761305

PCD10
Protocadherin-10

1

20

High-throughput

0.536

High

761309

PCDGK
Protocadherin gamma-C3

1

17

High-throughput

0.536

High

761315

PCDB2
Protocadherin beta-2

1

17

High-throughput

0.536

High

761316

PCDGL
Protocadherin gamma-C4

1

20

High-throughput

0.536

High

761318

PCDG7
Protocadherin gamma-A7

1

19

High-throughput

0.536

High

761319

PCDG6
Protocadherin gamma-A6

1

20

High-throughput

0.536

High

761320

PCDG5
Protocadherin gamma-A5

1

19

High-throughput

0.536

High

220116

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.513

High

761186

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

761198

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.513

High

761216

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

761257

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.513

High

761269

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.513

High

761275

SCTM1
Secreted and transmembrane protein 1

1

0

High-throughput

0.513

High

444917

S10A9
Protein S100-A9

1

7

High-throughput

0.500

High

533604

CLUS
Clusterin

1

6

High-throughput

0.500

High

557891

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.500

High

559235

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.500

High

761205

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.500

High

761304

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.500

High

326666

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.489

High

380739

HBD
Hemoglobin subunit delta

1

6

High-throughput

0.489

High

625988

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

5

High-throughput

0.489

High

761259

PGAM4
Probable phosphoglycerate mutase 4

1

4

High-throughput

0.489

High

649762

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.479

High

761194

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.479

High

71299

F1712
Protein FAM171A2

1

18

High-throughput

0.479

High

169458

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

179309

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

348386

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

Small-scale

0.479

High

371306

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

390473

TFR1
Transferrin receptor protein 1

1

8

Small-scale

0.479

High

413293

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

446695

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

474514

VIME
Vimentin

1

8

Small-scale

0.479

High

487008

PARP1
Poly [ADP-ribose] polymerase 1

1

11

Small-scale

0.479

High

507594

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.479

High

550882

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.479

High

577644

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

618221

CADH2
Cadherin-2

1

20

Small-scale

0.479

High

761183

CTNA1
Catenin alpha-1

1

15

Small-scale

0.479

High

761185

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

16

High-throughput

0.479

High

761187

S19A1
Reduced folate transporter

1

2

High-throughput

0.479

High

761191

TMEDA
Transmembrane emp24 domain-containing protein 10

1

7

Small-scale

0.479

High

761192

F10A1
Hsc70-interacting protein

1

19

Small-scale

0.479

High

761199

PSA
Puromycin-sensitive aminopeptidase

1

4

Small-scale

0.479

High

761203

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

Small-scale

0.479

High

761210

APLP2
Amyloid beta precursor like protein 2

1

10

Small-scale

0.479

High

761220

PWP1
Periodic tryptophan protein 1 homolog

1

16

High-throughput

0.479

High

761224

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

7

Small-scale

0.479

High

761238

AGK
Acylglycerol kinase, mitochondrial

1

3

Small-scale

0.479

High

761242

F1711
Protein FAM171A1

1

18

High-throughput

0.479

High

761249

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

10

Small-scale

0.479

High

761253

CCD25
Coiled-coil domain-containing protein 25

1

1

High-throughput

0.479

High

761260

NUP93
Nuclear pore complex protein Nup93

1

5

Small-scale

0.479

High

761261

PCD20
Protocadherin-20

1

20

Small-scale

0.479

High

761265

CNNM3
Metal transporter CNNM3

1

7

Small-scale

0.479

High

761267

VANG1
Vang-like protein 1

1

8

High-throughput

0.479

High

761274

FRS2
Fibroblast growth factor receptor substrate 2

1

20

High-throughput

0.479

High

761285

VPS35
Vacuolar protein sorting-associated protein 35

1

3

Small-scale

0.479

High

761288

TMM59
Transmembrane protein 59

1

4

Small-scale

0.479

High

761290

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.479

High

761291

CNNM2
Metal transporter CNNM2

1

7

Small-scale

0.479

High

761295

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

761297

ITM2C
Integral membrane protein 2C

1

6

Small-scale

0.479

High

761307

MRT4
mRNA turnover protein 4 homolog

1

6

High-throughput

0.479

High

761311

WASF3
Actin-binding protein WASF3

1

20

Small-scale

0.479

High

761312

ITM2B
Integral membrane protein 2B

1

6

Small-scale

0.479

High

761296

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

Small-scale

0.458

High

71706

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.437

High

280136

SC22B
Vesicle-trafficking protein SEC22b

1

11

High-throughput

0.437

High

281720

VP26A
Vacuolar protein sorting-associated protein 26A

1

4

Small-scale

0.437

High

338432

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

566576

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

761202

NOMO3
BOS complex subunit NOMO3

1

1

Small-scale

0.437

High

761229

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

761236

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

Small-scale

0.437

High

761264

TXND5
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.437

High

761277

WASF1
Actin-binding protein WASF1

1

20

Small-scale

0.437

High

761278

SEPT8
Septin-8

1

20

High-throughput

0.437

High

761313

NCKP1
Nck-associated protein 1

1

2

Small-scale

0.437

High

761314

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.437

High

761322

WASF2
Actin-binding protein WASF2

1

20

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025