HitPredict

Interactor 1: MED3 (P40356)
Mediator of RNA polymerase II transcription subunit 3 (Hyper-recombination suppressor protein 1) (Mediator complex subunit 3) (Poly-glutamine domain protein 1)
Gene: PGD1

Interactor 2: MED21 (P47822)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNAPII complex component SRB7) (Suppressor of RNA polymerase B 7)
Gene: SRB7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.55	0.658

The method score is based on:

Property	Details
Experiments	9420330, 15477388, 16554755, 37968396
Identification Methods	biochemical, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	association, direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0016592 - mediator complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II and 5 others more... GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070847 - core mediator complex
Homologous interactions	0

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Last updated: 15 Jul 2024