HitPredict

Interactor 1: COPB2 (P35606)
Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)
Gene: COPB2

Interactor 2: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arf~WD40
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 175
+	Hs
		612154 COPB2_HUMAN (1-906): 0: 734: 100.00		ARF4_HUMAN (1-173): 1.28e-70: 212: 64.74
+	Hs
		773479 COPB2_HUMAN (1-906): 0: 734: 100.00		ARF5_HUMAN (2-173): 5.22e-69: 208: 65.12
+	Dm
		264631 COPB2_DROME (1-906): 0: 636: 67.65		ARF4_DROME (1-173): 2.93e-69: 209: 65.32
+	Dm
		264632 COPB2_DROME (1-906): 0: 636: 67.65		ARF1_DROME (2-175): 1.28e-64: 197: 70.12
+	Sc
		536133 COPB2_YEAST (3-837): 1.39e-165: 507: 44.41		ARF1_YEAST (2-175): 9.86e-69: 208: 66.09
+	Sc
		536150 COPA_YEAST (175-526): 1.94e-57: 217: 13.08		ARF1_YEAST (2-175): 9.86e-69: 208: 66.09
+	Dm
		829700 Q9W0B8_DROME (4-485): 1.03e-50: 196: 12.55		ARF4_DROME (1-173): 2.93e-69: 209: 65.32
+	Hs
		921865 COPA_HUMAN (5-408): 1.24e-50: 195: 14.02		ARF5_HUMAN (2-173): 5.22e-69: 208: 65.12
+	Dm
		958911 Q9W0B8_DROME (4-485): 1.03e-50: 196: 12.55		ARF1_DROME (2-175): 1.28e-64: 197: 70.12
+	Hs
		612187 WDR5_HUMAN (553-671): 1.9e-18: 89.6: 10.48		ARF4_HUMAN (1-173): 1.28e-70: 212: 64.74
+	Hs
		964820 WDR5_HUMAN (553-671): 1.9e-18: 89.6: 10.48		RAB1A_HUMAN (1-174): 5.21e-67: 204: 18.99
+	Hs
		965231 WDR5_HUMAN (553-671): 1.9e-18: 89.6: 10.48		RAB1B_HUMAN (10-174): 1.02e-66: 203: 19.41