HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.939

The method score is based on:

Property Details
Experiments 29884807, 31839598, 18509338, 29610493, 29439243, 23975937
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, electron diffraction, x-ray crystallography, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
and 19 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 526
Hs

1 526
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025