HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	24378640
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 870
+	Hs
		777046 UBP8_HUMAN (1-1118): 0: 830: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1085724 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		292026 UBP2_MOUSE (529-1111): 9.36e-117: 376: 27.43		BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91
+	Hs
		301402 UBP19_HUMAN (887-1106): 1.35e-27: 123: 34.91		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Dm
		247722 Q9VDD8_DROME (9-660): 1.72e-64: 238: 20.63		CLOCK_DROME (16-651): 1.88e-96: 326: 16.62
+	Hs
		1024405 UBP4_HUMAN (964-1106): 5.42e-33: 140: 44.06		NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12