Protein: SORT
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)

Gene: SORT, SORT1
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q99523

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618296

BDNF
Brain-derived neurotrophic factor

5

7

Small-scale

0.918

High

351494

NGF
Beta-nerve growth factor

3

7

Small-scale

0.858

High

1304330

SORT
Sortilin

3

4

Small-scale

0.853

High

1264254

SORC1
VPS10 domain-containing receptor SorCS1

2

4

Small-scale

0.800

High

1304359

GGA1
ADP-ribosylation factor-binding protein GGA1

5

7

Small-scale

0.723

High

674713

AMRP
Alpha-2-macroglobulin receptor-associated protein

5

1

Small-scale

0.710

High

1304358

GGA2
ADP-ribosylation factor-binding protein GGA2

3

7

Small-scale

0.685

High

1269014

SORL
Sortilin-related receptor

1

4

Small-scale

0.647

High

385400

NTRK1
High affinity nerve growth factor receptor

2

7

Small-scale

0.641

High

436638

TNR16
Tumor necrosis factor receptor superfamily member 16

3

8

Small-scale

0.640

High

625572

CDK2
Cyclin-dependent kinase 2

2

1

High-throughput

0.621

High

1296153

SCYL1
N-terminal kinase-like protein

2

0

High-throughput

0.602

High

677620

NEUT
Neurotensin/neuromedin N [Cleaved into: Large neuromedin N

2

1

Small-scale

0.595

High

1081578

NTRK3
NT-3 growth factor receptor

1

7

Small-scale

0.589

High

1083882

NTRK2
BDNF/NT-3 growth factors receptor

1

7

Small-scale

0.589

High

364601

TRFE
Serotransferrin

2

0

High-throughput

0.580

High

1162848

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.580

High

1252713

CNIH3
Protein cornichon homolog 3

2

0

High-throughput

0.580

High

1295929

AGRG7
Adhesion G-protein coupled receptor G7

2

0

High-throughput

0.580

High

595723

NTF3
Neurotrophin-3

1

7

Small-scale

0.579

High

660678

GRN
Progranulin

2

0

Small-scale

0.569

High

395559

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.561

High

399184

IL6
Interleukin-6

1

1

Small-scale

0.561

High

413107

AGAL
Alpha-galactosidase A

1

0

Small-scale

0.545

High

296337

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

High-throughput

0.536

High

415035

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.536

High

434269

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

9

High-throughput

0.536

High

488350

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

528390

MYH6
Myosin-6

1

2

High-throughput

0.536

High

533163

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

1

High-throughput

0.536

High

598767

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

High-throughput

0.536

High

645819

CD27
CD27 antigen

1

6

High-throughput

0.536

High

654694

CALX
Calnexin

1

1

High-throughput

0.536

High

994790

GOGA3
Golgin subfamily A member 3

1

3

High-throughput

0.536

High

1067590

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.536

High

1127302

TGO1
Transport and Golgi organization protein 1 homolog

1

3

High-throughput

0.536

High

1161939

FOXR1
Forkhead box protein R1

1

1

High-throughput

0.536

High

1162560

TXD11
Thioredoxin domain-containing protein 11

1

3

High-throughput

0.536

High

1164574

NHS
Actin remodeling regulator NHS

1

1

High-throughput

0.536

High

1219439

LMTK2
Serine/threonine-protein kinase LMTK2

1

9

High-throughput

0.536

High

1221261

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

2

High-throughput

0.536

High

1223005

FANCM
Fanconi anemia group M protein

1

1

High-throughput

0.536

High

1244174

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

3

High-throughput

0.536

High

1262158

DNJA4
DnaJ homolog subfamily A member 4

1

2

High-throughput

0.536

High

1265934

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.536

High

1304334

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

3

High-throughput

0.536

High

1304336

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.536

High

1304360

ICAM5
Intercellular adhesion molecule 5

1

1

High-throughput

0.536

High

1304361

DICER
Endoribonuclease Dicer

1

1

High-throughput

0.536

High

1304362

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.536

High

1304364

KLDC2
Kelch domain-containing protein 2

1

1

High-throughput

0.536

High

1304366

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.536

High

64735

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.513

High

125666

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.513

High

131947

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

164658

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

0

High-throughput

0.513

High

206414

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.513

High

236028

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

236370

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.513

High

318870

K2C75
Keratin, type II cytoskeletal 75

1

0

High-throughput

0.513

High

321302

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.513

High

344004

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

428379

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

447755

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.513

High

451541

CLCA
Clathrin light chain A

1

0

High-throughput

0.513

High

501437

CD8B
T-cell surface glycoprotein CD8 beta chain

1

0

High-throughput

0.513

High

611700

EVI2A
Protein EVI2A

1

0

High-throughput

0.513

High

702285

CD70
CD70 antigen

1

0

High-throughput

0.513

High

789004

TEC
Tyrosine-protein kinase Tec

1

0

High-throughput

0.513

High

792837

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

795250

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.513

High

845877

RAB13
Ras-related protein Rab-13

1

0

High-throughput

0.513

High

849133

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.513

High

863529

COPA
Coatomer subunit alpha

1

0

High-throughput

0.513

High

870681

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

931358

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.513

High

943154

KC1G2
Casein kinase I isoform gamma-2

1

0

High-throughput

0.513

High

957769

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

High-throughput

0.513

High

968273

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

0

High-throughput

0.513

High

1034113

TCOF
Treacle protein

1

0

High-throughput

0.513

High

1035684

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.513

High

1046249

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

1051839

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.513

High

1056456

IRF3
Interferon regulatory factor 3

1

0

High-throughput

0.513

High

1057602

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.513

High

1076094

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.513

High

1081210

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

1

0

High-throughput

0.513

High

1145664

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

1154292

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.513

High

1160886

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1165029

CSPG4
Chondroitin sulfate proteoglycan 4

1

0

High-throughput

0.513

High

1193095

CENPV
Centromere protein V

1

0

High-throughput

0.513

High

1203174

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.513

High

1203331

GPBP1
Vasculin

1

0

High-throughput

0.513

High

1205947

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.513

High

1218616

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.513

High

1221892

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1225013

ABCA7
Phospholipid-transporting ATPase ABCA7

1

0

High-throughput

0.513

High

1237578

DDX51
ATP-dependent RNA helicase DDX51

1

0

High-throughput

0.513

High

1241112

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.513

High

1241394

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.513

High

1242112

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.513

High

1266021

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1272313

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.513

High

1273019

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.513

High

1273030

BAD
Bcl2-associated agonist of cell death

1

0

High-throughput

0.513

High

1299126

IPO9
Importin-9

1

0

High-throughput

0.513

High

1304333

RFIP5
Rab11 family-interacting protein 5

1

0

High-throughput

0.513

High

1304341

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

0

High-throughput

0.513

High

1304342

PALMD
Palmdelphin

1

0

High-throughput

0.513

High

1304343

BIN3
Bridging integrator 3

1

0

High-throughput

0.513

High

1304346

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

0

High-throughput

0.513

High

1304350

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

1304353

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.513

High

1304356

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.513

High

1304357

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.513

High

1304363

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

1304365

TLN1
Talin-1

1

0

High-throughput

0.513

High

1304369

MORC2
ATPase MORC2

1

0

High-throughput

0.513

High

420684

LIPL
Lipoprotein lipase

1

1

Small-scale

0.501

High

306853

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.493

High

1266283

FAM3C
Protein FAM3C

1

0

High-throughput

0.493

High

1304354

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

522563

MYH1
Myosin-1

1

2

High-throughput

0.489

High

1084760

TAZ
Tafazzin

1

1

High-throughput

0.489

High

1121926

COBL1
Cordon-bleu protein-like 1

1

1

High-throughput

0.489

High

1217337

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.489

High

1304332

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

1304335

WN10A
Protein Wnt-10a

1

1

High-throughput

0.489

High

1304337

TARA
TRIO and F-actin-binding protein

1

2

High-throughput

0.489

High

1304367

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

High-throughput

0.489

High

351803

THYG
Thyroglobulin

1

1

Small-scale

0.481

High

542654

LIF
Leukemia inhibitory factor

1

0

Small-scale

0.480

High

789681

LIFR
Leukemia inhibitory factor receptor

1

0

Small-scale

0.480

High

205874

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

231882

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

1

High-throughput

0.479

High

265790

CRLF1
Cytokine receptor-like factor 1

1

4

Small-scale

0.479

High

850163

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

869408

HAP1
Huntingtin-associated protein 1

1

3

Small-scale

0.479

High

882046

BACE1
Beta-secretase 1

1

1

Small-scale

0.479

High

964051

SRSF2
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.479

High

992385

KLC1
Kinesin light chain 1

1

1

High-throughput

0.479

High

1042360

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1117786

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.479

High

1187730

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

High-throughput

0.479

High

1242447

PAPD5
Terminal nucleotidyltransferase 4B

1

1

High-throughput

0.479

High

1270609

STAM1
Signal transducing adapter molecule 1

1

7

Small-scale

0.479

High

1271885

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.479

High

1304331

MPH6
M-phase phosphoprotein 6

1

1

High-throughput

0.479

High

1304348

GGA3
ADP-ribosylation factor-binding protein GGA3

1

7

Small-scale

0.479

High

1304355

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1304368

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

1

High-throughput

0.479

High

62472

HELT
Hairy and enhancer of split-related protein HELT

1

1

High-throughput

0.470

High

197810

CRX
Cone-rod homeobox protein

1

1

High-throughput

0.470

High

431269

CATB
Cathepsin B

1

0

High-throughput

0.458

High

779968

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

781029

OPRD
Delta-type opioid receptor

1

0

Small-scale

0.458

High

815810

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

1101239

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1119601

MIDN
Midnolin

1

0

High-throughput

0.458

High

1165887

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1269438

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1304340

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1304349

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1083848

CTF1
Cardiotrophin-1

1

2

Small-scale

0.457

High

87294

C9J6P4
Zinc finger CCCH-type containing, antiviral 1

1

2

High-throughput

0.445

High

103671

G5E9A6
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

111285

J3KP15
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.445

High

787681

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

686578

OTX2
Homeobox protein OTX2

1

1

High-throughput

0.437

High

1171378

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1298948

MUS81
Crossover junction endonuclease MUS81

1

1

High-throughput

0.437

High

1304338

ZN768
Zinc finger protein 768

1

2

High-throughput

0.437

High

1304351

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.437

High

1304352

CLCF1
Cardiotrophin-like cytokine factor 1

1

2

Small-scale

0.437

High

92741

E9PRI1
Crossover junction endonuclease MUS81

1

1

High-throughput

0.407

High

103500

G4U4J3
PAP associated domain containing 5

1

1

High-throughput

0.407

High

103892

G5E9S8
Kinesin light chain

1

1

High-throughput

0.407

High

108827

H0YAJ5
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.407

High

110630

H3BNT4
M-phase phosphoprotein 6

1

1

High-throughput

0.407

High

110669

H3BS42
Zinc finger protein 768

1

2

High-throughput

0.407

High

111267

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

1

High-throughput

0.407

High

51078

SPD2B
SH3 and PX domain-containing protein 2B

1

0

High-throughput

0.279

Low

207150

XRCC2
DNA repair protein XRCC2

1

0

High-throughput

0.279

Low

210580

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

230077

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.279

Low

319628

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

331870

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

341231

HPT
Haptoglobin

1

0

High-throughput

0.279

Low

802196

NOP2
Probable 28S rRNA

1

0

High-throughput

0.279

Low

1049390

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

0

High-throughput

0.279

Low

1083596

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1152941

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

1154111

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

0

High-throughput

0.279

Low

1174772

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.279

Low

1187467

APTX
Aprataxin

1

0

High-throughput

0.279

Low

1192708

RM55
Large ribosomal subunit protein mL55

1

0

High-throughput

0.279

Low

1217426

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.279

Low

1217730

S22A9
Organic anion transporter 7

1

0

High-throughput

0.279

Low

1220878

PHC2
Polyhomeotic-like protein 2

1

0

High-throughput

0.279

Low

1237854

CB069
Mitochondrial protein C2orf69

1

0

High-throughput

0.279

Low

1255189

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.279

Low

1255873

SSH3
Protein phosphatase Slingshot homolog 3

1

0

High-throughput

0.279

Low

1256117

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

0

High-throughput

0.279

Low

1270081

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.279

Low

1283360

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

1283703

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

1284706

EME1
Crossover junction endonuclease EME1

1

0

High-throughput

0.279

Low

1287152

FAF2
FAS-associated factor 2

1

0

High-throughput

0.279

Low

1297859

NSE2
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.279

Low

1304339

NOL6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

1304344

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

1304345

RBM28
RNA-binding protein 28

1

0

High-throughput

0.279

Low

1304347

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

642894

CNTF
Ciliary neurotrophic factor

1

0

Small-scale

0.275

Low

532863

ONCM
Oncostatin-M

1

0

Small-scale

0.261

Low

1238647

CDRT4
CMT1A duplicated region transcript 4 protein

1

0

High-throughput

0.249

Low

102442

G3V5I9
TVP23C-CDRT4 readthrough

1

0

High-throughput

0.232

Low

1032574

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024