HitPredict

Interactor 1: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Interactor 2: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 321
+	Hs
		783461 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2D4_HUMAN (4-153): 6.76e-77: 233: 31.33
+	Hs
		783205 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2D1_HUMAN (4-153): 1.58e-76: 232: 30.00
+	Hs
		783223 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2D2_HUMAN (4-153): 1.4e-76: 232: 34.67
+	Hs
		783212 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2D3_HUMAN (4-153): 2.71e-75: 229: 34.00
+	Hs
		783375 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2E2_HUMAN (3-153): 3.46e-68: 213: 23.18
+	Hs
		783206 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UB2E1_HUMAN (3-153): 6.41e-67: 209: 25.17
+	Hs
		144168 TRI23_HUMAN (1-574): 1.89e-139: 418: 100.00		UBE2C_HUMAN (9-145): 2.4e-20: 88.2: 35.77
+	Hs
		957053 ARF6_HUMAN (399-567): 1.79e-87: 270: 54.44		UB2D3_HUMAN (4-153): 2.71e-75: 229: 34.00