Protein: UBE2C
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)

Gene: UBE2C
Organism: Homo sapiens
Interactions: 58
UniProt ID: O00762

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

144197

APC11
Anaphase-promoting complex subunit 11

67

20

Small-scale

0.997

High

144164

UBA1
Ubiquitin-like modifier-activating enzyme 1

6

20

Small-scale

0.940

High

144149

UBE2C
Ubiquitin-conjugating enzyme E2 C

5

17

Small-scale

0.924

High

144198

RBX2
RING-box protein 2

4

20

Small-scale

0.899

High

144201

ANC2
Anaphase-promoting complex subunit 2

4

20

Small-scale

0.896

High

144158

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

144151

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.768

High

144174

CDC20
Cell division cycle protein 20 homolog

4

12

Small-scale

0.688

High

144202

FZR1
Fizzy-related protein homolog

4

7

Small-scale

0.686

High

144180

PCGF3
Polycomb group RING finger protein 3

1

20

High-throughput

0.656

High

144175

MK07
Mitogen-activated protein kinase 7

3

3

High-throughput

0.654

High

144152

TRI13
E3 ubiquitin-protein ligase TRIM13

1

20

Small-scale

0.647

High

144161

RAG1
V(D)J recombination-activating protein 1

1

20

Small-scale

0.647

High

144163

RO52
E3 ubiquitin-protein ligase TRIM21

1

20

Small-scale

0.647

High

144170

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

144181

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.647

High

144189

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

144190

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

144193

TRIM2
Tripartite motif-containing protein 2

1

20

Small-scale

0.647

High

144194

RN167
E3 ubiquitin-protein ligase RNF167

1

20

Small-scale

0.647

High

144203

CHIP
E3 ubiquitin-protein ligase CHIP

1

15

Small-scale

0.647

High

144204

RNF6
E3 ubiquitin-protein ligase RNF6

1

20

Small-scale

0.647

High

144160

PVR
Poliovirus receptor

2

3

High-throughput

0.628

High

144179

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

17

Small-scale

0.618

High

144185

RN133
E3 ubiquitin-protein ligase RNF133

1

20

Small-scale

0.618

High

144200

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

144168

TRI23
E3 ubiquitin-protein ligase TRIM23

1

8

Small-scale

0.575

High

144187

RYR2
Ryanodine receptor 2

1

10

Small-scale

0.561

High

144183

DTX1
E3 ubiquitin-protein ligase DTX1

1

20

High-throughput

0.541

High

144205

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

144157

ENOG
Gamma-enolase

1

0

High-throughput

0.518

High

144165

CXCR1
C-X-C chemokine receptor type 1

1

0

High-throughput

0.518

High

144172

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

0

High-throughput

0.518

High

144171

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.515

High

144150

AURKA
Aurora kinase A

1

3

Small-scale

0.501

High

144166

PSB5
Proteasome subunit beta type-5

1

6

Small-scale

0.501

High

144167

PRS7
26S proteasome regulatory subunit 7

1

1

Small-scale

0.501

High

144169

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

2

Small-scale

0.501

High

144173

TF65
Transcription factor p65

1

8

Small-scale

0.501

High

144176

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.501

High

144184

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

7

Small-scale

0.501

High

144195

DPOLM
DNA-directed DNA/RNA polymerase mu

1

8

Small-scale

0.501

High

144154

KLHL2
Kelch-like protein 2

1

7

High-throughput

0.481

High

144182

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

Small-scale

0.480

High

144153

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

144155

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

144156

EGFR
Epidermal growth factor receptor

1

4

Small-scale

0.479

High

144162

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

144188

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

144196

RN216
E3 ubiquitin-protein ligase RNF216

1

20

Small-scale

0.479

High

144199

DUX4
Double homeobox protein 4

1

1

High-throughput

0.479

High

144178

PAF15
PCNA-associated factor

1

0

Small-scale

0.458

High

144177

TRI29
Tripartite motif-containing protein 29

1

20

Small-scale

0.457

High

144191

RANB9
Ran-binding protein 9

1

10

High-throughput

0.457

High

144159

CADH1
Cadherin-1

1

0

Small-scale

0.426

High

144192

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.417

High

144186

CKAP2
Cytoskeleton-associated protein 2

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025