HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: TBA1A (Q71U36)
Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]
Gene: TUBA1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005874 - microtubule GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 451
+	Hs
		1035018 KPCE_HUMAN (3-375): 7.05e-123: 374: 19.01		TBA1C_HUMAN (1-451): 0: 722: 98.00
+	Hs
		783651 MP2K2_HUMAN (1-400): 2.9e-127: 374: 100.00		TBA1C_HUMAN (1-451): 0: 722: 98.00
+	Hs
		783555 MP2K2_HUMAN (1-400): 2.9e-127: 374: 100.00		TBA4A_HUMAN (1-450): 0: 714: 96.00
+	Hs
		668012 CDK2_HUMAN (69-375): 1.37e-125: 365: 25.16		TBA1C_HUMAN (1-451): 0: 722: 98.00
+	Hs
		783554 MP2K2_HUMAN (1-400): 2.9e-127: 374: 100.00		TBA1B_HUMAN (1-440): 0: 712: 99.55
+	Hs
		996665 KPCE_HUMAN (3-375): 7.05e-123: 374: 19.01		TBA1B_HUMAN (1-440): 0: 712: 99.55
+	Hs
		728308 AKT1_HUMAN (43-351): 2.64e-124: 369: 20.12		TBA1A_HUMAN (1-451): 0: 710: 100.00
+	Dm
		444141 DSOR1_DROME (28-397): 5.16e-125: 368: 62.70		TBA3_DROME (1-439): 0: 705: 97.49
+	Hs
		457269 MP2K2_HUMAN (1-400): 2.9e-127: 374: 100.00		TBB5_HUMAN (1-439): 0: 696: 40.77
+	Hs
		457375 KPCE_HUMAN (3-375): 7.05e-123: 374: 19.01		TBB5_HUMAN (1-439): 0: 696: 40.77
+	Hs
		783556 MP2K2_HUMAN (1-400): 2.9e-127: 374: 100.00		TBB4B_HUMAN (1-437): 0: 694: 40.50
+	Hs
		997290 KPCE_HUMAN (3-375): 7.05e-123: 374: 19.01		TBB4B_HUMAN (1-437): 0: 694: 40.50
+	Hs
		457255 AKT1_HUMAN (43-351): 2.64e-124: 369: 20.12		TBB5_HUMAN (1-439): 0: 696: 40.77
+	Hs
		728160 AKT1_HUMAN (43-351): 2.64e-124: 369: 20.12		TBB4B_HUMAN (1-437): 0: 694: 40.50
+	Hs
		667758 CDK2_HUMAN (69-375): 1.37e-125: 365: 25.16		TBB4B_HUMAN (1-437): 0: 694: 40.50
+	Hs
		1093168 STK4_HUMAN (41-377): 2.66e-109: 331: 28.74		TBA1C_HUMAN (1-451): 0: 722: 98.00
+	Hs
		996926 STK4_HUMAN (41-377): 2.66e-109: 331: 28.74		TBA4A_HUMAN (1-450): 0: 714: 96.00
+	Ce
		115826 GCK1_CAEEL (72-377): 8.38e-107: 330: 30.20		O18688_CAEEL (1-439): 0: 700: 87.70
+	Hs
		997305 STK4_HUMAN (41-377): 2.66e-109: 331: 28.74		TBB4B_HUMAN (1-437): 0: 694: 40.50
+	Hs
		443123 CDK1_HUMAN (69-375): 1.56e-110: 327: 24.76		TBB5_HUMAN (1-439): 0: 696: 40.77