Protein: RFC4
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)

Gene: RFC4
Organism: Homo sapiens
Interactions: 185
UniProt ID: P35249

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003689 - DNA clamp loader activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

721936

RFC5
Replication factor C subunit 5

15

16

Small-scale

0.986

High

721937

RFC3
Replication factor C subunit 3

8

16

Small-scale

0.971

High

721933

RFC2
Replication factor C subunit 2

9

16

Small-scale

0.967

High

517099

PCNA
Proliferating cell nuclear antigen

6

12

Small-scale

0.944

High

722022

ATAD5
ATPase family AAA domain-containing protein 5

5

20

Small-scale

0.922

High

721934

RFC1
Replication factor C subunit 1

4

17

Small-scale

0.896

High

722015

CTF18
Chromosome transmission fidelity protein 18 homolog

3

17

Small-scale

0.879

High

226670

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.754

High

346080

MYC
Myc proto-oncogene protein

6

3

High-throughput

0.726

High

278999

RAD17
Cell cycle checkpoint protein RAD17

5

20

Small-scale

0.721

High

244021

BRD4
Bromodomain-containing protein 4

5

10

Small-scale

0.717

High

722030

DCC1
Sister chromatid cohesion protein DCC1

3

7

High-throughput

0.667

High

722039

RNF41
E3 ubiquitin-protein ligase NRDP1

5

3

Small-scale

0.658

High

719810

RFA3
Replication protein A 14 kDa subunit

3

3

High-throughput

0.656

High

650501

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

3

Small-scale

0.640

High

238255

RAD1
Cell cycle checkpoint protein RAD1

2

2

High-throughput

0.628

High

474570

CTF8
Chromosome transmission fidelity protein 8 homolog

2

2

High-throughput

0.628

High

722055

UBQL2
Ubiquilin-2

1

1

High-throughput

0.618

High

722060

RUVB2
RuvB-like 2

1

11

High-throughput

0.618

High

721952

EPHA4
Ephrin type-A receptor 4

2

0

High-throughput

0.602

High

721992

TAF12
Transcription initiation factor TFIID subunit 12

2

0

High-throughput

0.602

High

722001

TAF2
Transcription initiation factor TFIID subunit 2

2

0

High-throughput

0.602

High

722043

TAF9B
Transcription initiation factor TFIID subunit 9B

2

0

High-throughput

0.602

High

721954

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

2

Small-scale

0.595

High

386206

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

552071

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.584

High

721961

H4
Histone H4

2

7

High-throughput

0.584

High

721964

H31
Histone H3.1

2

13

High-throughput

0.584

High

721991

BRD3
Bromodomain-containing protein 3

2

13

High-throughput

0.584

High

722046

ANLN
Anillin

2

3

High-throughput

0.584

High

722047

MCM9
DNA helicase MCM9

2

4

Small-scale

0.584

High

721988

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

722018

ESR2
Estrogen receptor beta

2

6

High-throughput

0.571

High

721977

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.561

High

71076

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

133345

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

245882

HUS1
Checkpoint protein HUS1

1

2

High-throughput

0.536

High

417986

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

455148

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.536

High

469959

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

508367

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

649334

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

721950

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

721958

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

721968

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

721972

FAK1
Focal adhesion kinase 1

1

4

High-throughput

0.536

High

721973

SSRP1
FACT complex subunit SSRP1

1

11

High-throughput

0.536

High

721995

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.536

High

722025

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.536

High

722028

RAD9A
Cell cycle checkpoint control protein RAD9A

1

3

High-throughput

0.536

High

722031

HIRP3
HIRA-interacting protein 3

1

1

High-throughput

0.536

High

722050

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.536

High

722059

SRPK3
SRSF protein kinase 3

1

7

High-throughput

0.536

High

722065

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

721993

FSCN1
Fascin

2

1

Small-scale

0.521

High

721940

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

721941

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

721946

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

721986

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

722016

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

722061

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.513

High

722067

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

721957

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

722024

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.493

High

722019

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.489

High

722054

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.489

High

722058

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.489

High

122521

MEN1
Menin

1

3

High-throughput

0.479

High

125189

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

148456

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

150884

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

282554

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

294450

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

298210

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

302965

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

312022

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

3

Small-scale

0.479

High

317917

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

6

High-throughput

0.479

High

338029

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

373786

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

384379

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

391575

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.479

High

441905

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

472682

FBSP1
F-box/SPRY domain-containing protein 1

1

4

High-throughput

0.479

High

487914

RARA
Retinoic acid receptor alpha

1

6

Small-scale

0.479

High

569289

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

622372

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

631359

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

668470

PML
Protein PML

1

4

Small-scale

0.479

High

721935

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

721938

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

721939

NKX21
Homeobox protein Nkx-2.1

1

4

High-throughput

0.479

High

721943

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

721947

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

721949

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

721951

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

721953

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

721959

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

721960

RS6
Small ribosomal subunit protein eS6

1

6

High-throughput

0.479

High

721962

H2B1C
Histone H2B type 1-C/E/F/G/I

1

14

High-throughput

0.479

High

721963

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

721966

H33
Histone H3.3

1

13

High-throughput

0.479

High

721967

VIGLN
Vigilin

1

4

High-throughput

0.479

High

721971

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

721974

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

721975

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

721978

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

721980

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

High-throughput

0.479

High

721981

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

721982

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

721983

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.479

High

721984

CUL3
Cullin-3

1

4

High-throughput

0.479

High

721989

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.479

High

721990

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

721994

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.479

High

721998

MYSM1
Deubiquitinase MYSM1

1

1

Small-scale

0.479

High

722000

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

722003

PAXI1
PAX-interacting protein 1

1

8

High-throughput

0.479

High

722004

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

722005

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

722006

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

722007

SETD3
Actin-histidine N-methyltransferase

1

1

High-throughput

0.479

High

722011

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

722013

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.479

High

722014

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

722017

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

722023

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

722026

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

722027

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

722029

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

722032

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

Small-scale

0.479

High

722033

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

722035

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

722036

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

722037

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

722040

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

722042

PIDD1
p53-induced death domain-containing protein 1

1

1

Small-scale

0.479

High

722044

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

722049

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

722052

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

722057

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

722063

FAN1
Fanconi-associated nuclease 1

1

1

Small-scale

0.479

High

722064

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

722066

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

722062

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

3

High-throughput

0.470

High

666363

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

721956

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

721965

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

Small-scale

0.458

High

721969

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

721976

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

722008

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

722010

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

722034

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

722048

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

722051

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

722053

TES
Testin

1

0

High-throughput

0.458

High

256948

KDM4A
Lysine-specific demethylase 4A

1

6

Small-scale

0.445

High

401515

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

528667

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

721979

STF1
Steroidogenic factor 1

1

5

Small-scale

0.445

High

721996

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

721999

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.445

High

722012

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

722041

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

721985

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.437

High

721987

GRB7
Growth factor receptor-bound protein 7

1

1

Small-scale

0.437

High

722002

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

722009

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.437

High

722020

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

722038

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

722045

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

722056

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

721945

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

949

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

721955

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.407

High

721970

TAGL
Transgelin

1

1

High-throughput

0.407

High

721997

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

319519

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

581246

LFA3
Lymphocyte function-associated antigen 3

1

0

High-throughput

0.279

Low

721942

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

721944

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

721948

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.279

Low

362878

FINC
Fibronectin

1

0

High-throughput

0.249

Low

722021

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.249

Low

581485

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

596508

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024