HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: LRRC1 (Q9BTT6)
Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein)
Gene: LRRC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	26186194, 27880917, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~Metallophos, LRR_8~STPPase_N
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 524
+	Hs
		786799 PP1G_HUMAN (1-323): 0: 603: 100.00		ERBIN_HUMAN (177-523): 1.34e-46: 177: 23.78
+	Hs
		786599 PP1G_HUMAN (1-323): 0: 603: 100.00		SCRIB_HUMAN (209-522): 2.89e-45: 173: 21.45
+	Hs
		967931 PP1A_HUMAN (1-323): 0: 579: 90.66		ERBIN_HUMAN (177-523): 1.34e-46: 177: 23.78
+	Hs
		967723 PP1A_HUMAN (1-323): 0: 579: 90.66		SCRIB_HUMAN (209-522): 2.89e-45: 173: 21.45
+	Hs
		786579 PP1G_HUMAN (1-323): 0: 603: 100.00		FLII_HUMAN (5-207): 2.52e-34: 140: 28.02
+	Hs
		968296 PP1B_HUMAN (1-322): 0: 560: 86.89		SCRIB_HUMAN (209-522): 2.89e-45: 173: 21.45
+	Hs
		967696 PP1A_HUMAN (1-323): 0: 579: 90.66		FLII_HUMAN (5-207): 2.52e-34: 140: 28.02
+	Hs
		967924 PP1A_HUMAN (1-323): 0: 579: 90.66		LRRC7_HUMAN (245-523): 9.51e-29: 123: 17.50
+	Hs
		786937 PP1G_HUMAN (1-323): 0: 603: 100.00		SHOC2_HUMAN (309-522): 4.99e-21: 98.3: 17.21
+	Dm
		559065 PP12_DROME (5-303): 0: 551: 93.31		SUR8_DROME (176-523): 4.18e-38: 150: 24.00
+	Hs
		968279 PP1B_HUMAN (1-322): 0: 560: 86.89		FLII_HUMAN (5-207): 2.52e-34: 140: 28.02
+	Hs
		967947 PP1A_HUMAN (1-323): 0: 579: 90.66		LRRC1_HUMAN (278-522): 1.44e-21: 99: 17.41
+	Hs
		968040 PP1A_HUMAN (1-323): 0: 579: 90.66		SHOC2_HUMAN (309-522): 4.99e-21: 98.3: 17.21
+	Hs
		968429 PP1B_HUMAN (1-322): 0: 560: 86.89		LRRC1_HUMAN (278-522): 1.44e-21: 99: 17.41
+	Hs
		968489 PP1B_HUMAN (1-322): 0: 560: 86.89		SHOC2_HUMAN (309-522): 4.99e-21: 98.3: 17.21
+	Mm
		968131 PP1A_MOUSE (1-323): 0: 579: 90.36		LRRC1_MOUSE (370-524): 2.1e-09: 61.9: 10.97
+	Dm
		559041 PP12_DROME (5-303): 0: 551: 93.31		SCRIB_DROME (370-524): 3.3e-17: 87.7: 8.92