HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	9723620, 16429130, 15809337, 35044719, 21115825, 18375383, 18200045
Identification Methods	affinity chromatography technology, pull down, far western blotting, unspecified method, phage display, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 576
+	Hs
		787913 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		787969 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Rn
		1126747 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		SYNJ1_RAT (246-575): 3.51e-15: 81.2: 14.67
+	Mm
		1194353 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		1331796 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		522614 MYH7_HUMAN (256-608): 1.36e-14: 80.6: 11.14		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Mm
		1194352 EHD1_MOUSE (17-102): 8.82e-16: 83.5: 32.56		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		1353935 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Mm
		1194350 EHD2_MOUSE (19-102): 1.73e-12: 73.1: 27.38		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Ce
		1308345 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q9BI72_CAEEL (1-477): 2.39e-73: 243: 32.72
+	Hs
		307533 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Ce
		1308343 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q9BI71_CAEEL (1-477): 3.43e-72: 240: 32.52
+	Ce
		1259347 Q8WSP1_CAEEL (117-215): 2.67e-20: 98.2: 50.51		Q9BI72_CAEEL (1-477): 2.39e-73: 243: 32.72
+	Dm
		91160 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		Q7KU90_DROME (1-571): 4.4e-58: 209: 31.51
+	Sc
		710409 EDE1_YEAST (3-327): 3e-15: 82.9: 24.01		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		759286 END3_YEAST (15-378): 4.53e-13: 73.6: 17.73		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Hs
		1328938 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Sc
		759270 END3_YEAST (15-378): 4.53e-13: 73.6: 17.73		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Mm
		1265097 EHD1_MOUSE (17-102): 8.82e-16: 83.5: 32.56		EPN3_MOUSE (1-571): 2.38e-50: 185: 37.05
+	Hs
		203228 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11