HitPredict

Interactor 1: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 11242052, 15507451, 17437405, 18723680, 15941357, 12620238, 12181739, 8900201, 11230124
Identification Methods enzymatic study, protease assay, affinity chromatography technology, experimental interaction detection
Interaction Type direct interaction, cleavage reaction, physical association, protein cleavage, association

The annotation score is based on:

Property Details
Interacting Pfam domains Peptidase_C14~Peptidase_C14
Common GO terms GO:0001666 - response to hypoxia
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 19 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 277
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024