HitPredict

Interactor 1: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: BIRC7 (Q96CA5)
Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
Gene: BIRC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	11024045, 23563149, 11084335
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 277 Hs			1 298
+	Hs
		876960 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		BIRC7_HUMAN (1-298): 4.39e-104: 307: 100.00
+	Hs
		788230 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Hs
		177658 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		BIRC5_HUMAN (78-162): 8.85e-30: 111: 32.22
+	Hs
		788193 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		788194 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Mm
		140026 CASP3_MOUSE (1-277): 1.35e-141: 400: 86.64		BIRC3_MOUSE (84-161): 1.59e-20: 93.5: 38.46
+	Hs
		788182 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		876964 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Mm
		936913 CASP3_MOUSE (1-277): 1.35e-141: 400: 86.64		XIAP_MOUSE (1-96): 2.2e-12: 68.9: 18.18
+	Hs
		177663 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		BIRC5_HUMAN (78-162): 8.85e-30: 111: 32.22
+	Hs
		876944 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		876945 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Hs
		876939 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Mm
		957027 CASP7_MOUSE (37-275): 4.8e-115: 334: 59.50		XIAP_MOUSE (1-96): 2.2e-12: 68.9: 18.18
+	Dm
		136289 DRICE_DROME (36-275): 1.57e-101: 301: 41.94		DIAP1_DROME (77-253): 8.76e-22: 96.6: 20.23
+	Dm
		137119 CASP1_DROME (35-275): 1.11e-100: 298: 39.02		DIAP1_DROME (77-253): 8.76e-22: 96.6: 20.23
+	Mm
		140032 CASP9_MOUSE (34-275): 7.91e-95: 288: 35.77		BIRC3_MOUSE (84-161): 1.59e-20: 93.5: 38.46
+	Hs
		877014 CASP6_HUMAN (10-276): 2.26e-103: 304: 38.57		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Dm
		136290 DRICE_DROME (36-275): 1.57e-101: 301: 41.94		DIAP2_DROME (84-207): 3.25e-11: 65.4: 24.43
+	Rn
		1337442 Q9JHK1_RAT (34-275): 5.36e-97: 293: 35.77		XIAP_RAT (1-96): 1.08e-11: 66.9: 16.16