HitPredict

Interactor 1: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Interactor 2: BID (P55957)
BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]
Gene: BID

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	11399776, 11832478
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043065 - positive regulation of apoptotic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 452 Hs			1 195
+	Hs
		879522 CASP8_HUMAN (32-446): 1.84e-120: 361: 21.29		BID_HUMAN (1-195): 5.35e-103: 296: 100.00
+	Mm
		936811 CASP3_MOUSE (187-446): 3.09e-108: 323: 27.97		BID_MOUSE (1-195): 1.78e-109: 312: 64.14
+	Hs
		788172 CASP3_HUMAN (188-446): 3.26e-108: 323: 28.85		BID_HUMAN (1-195): 5.35e-103: 296: 100.00
+	Hs
		879539 CASPA_HUMAN (16-396): 7.11e-100: 310: 23.66		BID_HUMAN (1-195): 5.35e-103: 296: 100.00