HitPredict

Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	9809064, 15383276, 17161366
Identification Methods	two hybrid, pull down, affinity chromatography technology, nuclear magnetic resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 3142 Hs			1 347
+	Hs
		791911 HD_HUMAN (1-3142): 0: 5724: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		792017 HD_HUMAN (1-3142): 0: 5724: 100.00		SHLB2_HUMAN (10-342): 1.05e-58: 196: 20.57
+	Hs
		791942 HD_HUMAN (1-3142): 0: 5724: 100.00		PACN1_HUMAN (6-342): 5.44e-34: 131: 14.90
+	Hs
		791938 HD_HUMAN (1-3142): 0: 5724: 100.00		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		791466 HD_HUMAN (1-3142): 0: 5724: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		103061 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		SH3G3_MOUSE (1-346): 1.4e-88: 271: 86.71
+	Mm
		103060 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Mm
		103059 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		SH3G1_MOUSE (1-347): 3.99e-79: 247: 66.85
+	Mm
		103251 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		SHLB1_MOUSE (10-342): 1.64e-66: 215: 23.65
+	Mm
		103300 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		PACN2_MOUSE (1-343): 7.01e-37: 140: 16.45