Protein: TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)

Gene: TRHDE
Organism: Homo sapiens
Interactions: 28
UniProt ID: Q9UKU6

Gene Ontology (top 5):
GO:0004177 - aminopeptidase activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249272

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

2

2

High-throughput

0.628

High

252730

TSN3
Tetraspanin-3

2

3

High-throughput

0.628

High

699245

CALX
Calnexin

2

5

High-throughput

0.628

High

1381410

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

2

High-throughput

0.628

High

1458673

DNJB9
DnaJ homolog subfamily B member 9

2

5

High-throughput

0.628

High

1461237

MAN1
Inner nuclear membrane protein Man1

2

1

High-throughput

0.628

High

1131248

MESD
LRP chaperone MESD

2

0

High-throughput

0.602

High

1417550

EMIL2
EMILIN-2

2

3

High-throughput

0.574

High

1451241

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

2

1

High-throughput

0.574

High

380379

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

10

High-throughput

0.536

High

728474

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.536

High

1257563

TMTC3
Protein O-mannosyl-transferase TMTC3

1

3

High-throughput

0.536

High

328760

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.513

High

1394690

KIRR1
Kin of IRRE-like protein 1

1

0

High-throughput

0.513

High

1461238

ICOS
Inducible T-cell costimulator

1

0

High-throughput

0.513

High

1058716

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.493

High

388752

C1QB
Complement C1q subcomponent subunit B

1

2

High-throughput

0.489

High

976878

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.489

High

364009

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

1448316

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

516785

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

1358139

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

351748

SG1D1
Secretoglobin family 1D member 1

1

3

High-throughput

0.445

High

171016

CLGN
Calmegin

1

5

High-throughput

0.407

High

1227681

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

1210419

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

2

0

High-throughput

0.328

High

49826

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

1347308

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025