HitPredict

Interactor 1: ZAP70 (P43404)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: UBS3A (Q3V3E1)
Ubiquitin-associated and SH3 domain-containing protein A (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: Ubash3a

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24584089
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Mm			1 624
+	Hs
		796463 ZAP70_HUMAN (1-618): 0: 615: 93.39		UBS3A_HUMAN (1-624): 0: 991: 78.40
+	Hs
		796615 KSYK_HUMAN (1-598): 0: 543: 54.05		UBS3B_HUMAN (1-618): 0: 914: 46.00
+	Hs
		337511 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		UBS3B_HUMAN (1-618): 0: 914: 46.00
+	Mm
		796503 ZAP70_MOUSE (1-618): 0: 635: 100.00		GRB2_MOUSE (140-303): 3.25e-46: 164: 21.69
+	Hs
		796465 ZAP70_HUMAN (1-618): 0: 615: 93.39		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		796538 KSYK_HUMAN (1-598): 0: 543: 54.05		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		924590 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		665389 EPHA3_HUMAN (54-614): 1.02e-155: 474: 23.89		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		872610 EPHB1_HUMAN (66-603): 8.04e-154: 469: 26.57		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		337418 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		789054 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		872630 EPHA4_HUMAN (54-612): 1.06e-150: 461: 24.04		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		69206 A9UF07_HUMAN (109-596): 2.65e-144: 460: 28.09		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		235462 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		235483 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		337608 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		CD2AP_HUMAN (170-340): 1.1e-25: 114: 20.57
+	Hs
		298944 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86
+	Hs
		298959 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86
+	Hs
		337548 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		SRBS1_HUMAN (189-301): 6.91e-24: 109: 27.97
+	Hs
		337466 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		GRAP_HUMAN (140-301): 1.34e-25: 106: 17.47