Protein: VTC4
Vacuolar transporter chaperone complex subunit 4 (Phosphate metabolism protein 3) (Polyphosphate kinase) (SPX-dependent polyphosphate polymerase VTC subunit 4) (Vacuolar membrane polyphosphate polymerase catalytic subunit) (PolyP polymerase) (EC 2.7.4.1)

Gene: VTC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P47075

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0000421 - autophagosome membrane
GO:0000822 - inositol hexakisphosphate binding
GO:0005516 - calmodulin binding
GO:0005774 - vacuolar membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864896

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

5

15

Small-scale

0.912

High

849959

VTC2
Vacuolar transporter chaperone complex subunit 2

3

15

Small-scale

0.840

High

817474

VTC1
Vacuolar transporter chaperone complex subunit 1

2

15

Small-scale

0.789

High

740078

VPP1
V-type proton ATPase subunit a, vacuolar isoform

2

7

Small-scale

0.611

High

808352

VTC5
Vacuole transporter chaperone complex subunit 5

2

4

Small-scale

0.584

High

449144

CALM
Calmodulin

1

2

Small-scale

0.561

High

448261

HIP1
Histidine permease

1

2

High-throughput

0.541

High

583750

DAL5
Allantoate permease

1

2

High-throughput

0.541

High

796980

PHO88
SRP-independent targeting protein 3

1

2

High-throughput

0.541

High

864902

PIN3
[PSI+] inducibility protein 3

1

4

High-throughput

0.518

High

737232

HXT1
Low-affinity glucose transporter HXT1

1

0

High-throughput

0.518

High

863375

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

0

High-throughput

0.518

High

864890

GUP1
Membrane-bound O-acyltransferase GUP1

1

0

High-throughput

0.518

High

864898

PFA5
Palmitoyltransferase PFA5

1

0

High-throughput

0.518

High

864901

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.518

High

836994

MEP2
Ammonium transporter MEP2

1

1

Small-scale

0.504

High

547063

PPB
Repressible alkaline phosphatase

1

5

High-throughput

0.479

High

575732

BPT1
Bile pigment transporter 1

1

17

High-throughput

0.479

High

592342

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.479

High

603502

VATA
V-type proton ATPase catalytic subunit A

1

9

High-throughput

0.479

High

618879

GAP1
General amino-acid permease GAP1

1

2

Small-scale

0.479

High

628269

ZRC1
Vacuolar zinc transporter ZRC1

1

9

High-throughput

0.479

High

645841

VATE
V-type proton ATPase subunit E

1

5

High-throughput

0.479

High

673302

ADP1
Probable ATP-dependent permease

1

7

High-throughput

0.479

High

679832

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

693198

PHO91
Low-affinity phosphate transporter PHO91

1

10

High-throughput

0.479

High

726578

VATC
V-type proton ATPase subunit C

1

1

High-throughput

0.479

High

735737

VA0D
V-type proton ATPase subunit d

1

5

High-throughput

0.479

High

736196

YBT1
ATP-dependent bile acid permease

1

17

High-throughput

0.479

High

743470

SEC17
Alpha-soluble NSF attachment protein

1

2

High-throughput

0.479

High

743699

VATD
V-type proton ATPase subunit D

1

5

High-throughput

0.479

High

745216

COT1
Vacuolar zinc transporter COT1

1

9

High-throughput

0.479

High

746012

VATL2
V-type proton ATPase subunit c'

1

5

High-throughput

0.479

High

747929

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

780776

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

4

High-throughput

0.479

High

796497

PFF1
Vacuolar membrane protease

1

5

High-throughput

0.479

High

811626

YCFI
Metal resistance protein YCF1

1

17

High-throughput

0.479

High

811665

VATF
V-type proton ATPase subunit F

1

4

High-throughput

0.479

High

815867

KC13
Casein kinase I homolog 3

1

4

High-throughput

0.479

High

815980

VAC8
Vacuolar protein 8

1

4

High-throughput

0.479

High

825943

SYG1
Protein SYG1

1

10

High-throughput

0.479

High

843157

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

10

High-throughput

0.479

High

850713

RMD8
Sporulation protein RMD8

1

11

High-throughput

0.479

High

864888

VATG
V-type proton ATPase subunit G

1

6

High-throughput

0.479

High

864891

VOA1
V0 assembly protein 1

1

3

High-throughput

0.479

High

864892

VSB1
Vacuolar basic amino acid transporter VSB1

1

5

High-throughput

0.479

High

864895

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.479

High

864899

RMD1
Sporulation protein RMD1

1

11

High-throughput

0.479

High

864903

CSC1
Calcium permeable stress-gated cation channel 1

1

2

High-throughput

0.479

High

864907

SMF3
Iron transporter SMF3

1

3

High-throughput

0.479

High

864908

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

864909

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

4

High-throughput

0.479

High

864911

NYV1
Vacuolar v-SNARE NYV1

1

6

High-throughput

0.479

High

864912

YVC1
Calcium channel YVC1

1

5

High-throughput

0.479

High

864913

YPK9
Vacuolar cation-transporting ATPase YPK9

1

5

High-throughput

0.479

High

864914

VCX1
Vacuolar calcium ion transporter

1

10

High-throughput

0.479

High

737897

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

795433

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

864893

LSB1
LAS seventeen-binding protein 1

1

4

High-throughput

0.457

High

527055

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

741882

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

510616

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.437

High

558788

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

579660

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.437

High

647154

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.437

High

704791

MSP1
Outer mitochondrial transmembrane helix translocase

1

2

Small-scale

0.437

High

707512

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.437

High

709852

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

727148

HS104
Heat shock protein 104

1

4

High-throughput

0.437

High

780501

MCR1
NADH-cytochrome b5 reductase 2

1

1

Small-scale

0.437

High

795077

NU170
Nucleoporin NUP170

1

6

High-throughput

0.437

High

812446

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

824907

TM108
Protein TMA108

1

2

High-throughput

0.437

High

864889

TOM22
Mitochondrial import receptor subunit TOM22

1

2

High-throughput

0.437

High

864894

H3
Histone H3

1

5

High-throughput

0.437

High

864897

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

864900

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

864904

SGO1
Shugoshin

1

1

High-throughput

0.437

High

864906

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

864910

NCE2
Non-classical export protein 2

1

0

High-throughput

0.426

High

392972

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.407

High

509619

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.407

High

819143

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.407

High

94570

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

738874

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

864905

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025