HitPredict

Interactor 1: GATA4 (P43694)
Transcription factor GATA-4 (GATA-binding factor 4)
Gene: GATA4

Interactor 2: MTA3 (Q9BTC8)
Metastasis-associated protein MTA3
Gene: MTA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35182466
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GATA~GATA
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043565 - sequence-specific DNA binding GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 442 Hs			1 594
+	Hs
		1312040 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		MTA3_HUMAN (1-594): 0: 724: 100.00
+	Hs
		798887 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		MTA1_HUMAN (1-586): 0: 627: 69.14
+	Hs
		295956 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		MTA2_HUMAN (1-584): 0: 611: 64.40
+	Hs
		620565 GATA3_HUMAN (43-387): 3.5e-35: 137: 35.17		MTA3_HUMAN (1-594): 0: 724: 100.00
+	Hs
		1031969 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		MTA1_HUMAN (1-586): 0: 627: 69.14
+	Hs
		296168 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		MTA2_HUMAN (1-584): 0: 611: 64.40
+	Mm
		570301 GATA1_MOUSE (52-419): 4.58e-38: 144: 32.88		MTA2_MOUSE (1-584): 0: 613: 64.57
+	Hs
		799053 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		620449 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		554535 GATA1_HUMAN (90-422): 4.68e-40: 150: 35.44		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		620436 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		RCOR3_HUMAN (150-571): 3.76e-83: 270: 19.03
+	Hs
		1355449 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		RCOR1_HUMAN (148-567): 3.74e-78: 257: 16.63
+	Hs
		554529 GATA1_HUMAN (90-422): 4.68e-40: 150: 35.44		RCOR3_HUMAN (150-571): 3.76e-83: 270: 19.03
+	Hs
		620439 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		RCOR1_HUMAN (148-567): 3.74e-78: 257: 16.63
+	Hs
		620586 GATA3_HUMAN (43-387): 3.5e-35: 137: 35.17		RCOR3_HUMAN (150-571): 3.76e-83: 270: 19.03
+	Hs
		620368 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		MDEAS_HUMAN (142-457): 8.31e-49: 185: 14.82
+	Hs
		620517 GATA3_HUMAN (43-387): 3.5e-35: 137: 35.17		MDEAS_HUMAN (142-457): 8.31e-49: 185: 14.82
+	Hs
		261432 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		261404 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		261405 GATA3_HUMAN (43-387): 3.5e-35: 137: 35.17		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54