Protein: LRSM1
E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)

Gene: LRSM1, LRSAM1
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q6UWE0

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006914 - autophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957764

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

5

Small-scale

0.862

High

906681

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

6

Small-scale

0.857

High

1248420

LRSM1
E3 ubiquitin-protein ligase LRSAM1

2

20

Small-scale

0.781

High

1248438

TS101
Tumor susceptibility gene 101 protein

10

2

Small-scale

0.761

High

909330

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

High-throughput

0.698

High

957104

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

High-throughput

0.698

High

970675

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.698

High

982215

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

High-throughput

0.698

High

1248433

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

7

High-throughput

0.698

High

1248454

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

6

High-throughput

0.698

High

1248455

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

20

High-throughput

0.698

High

1122264

SCRIB
Protein scribble homolog

1

20

High-throughput

0.691

High

1248448

RAI14
Ankycorbin

1

9

High-throughput

0.691

High

179725

MDM4
Protein Mdm4

1

0

High-throughput

0.663

High

1156524

CCDC6
Coiled-coil domain-containing protein 6

3

6

High-throughput

0.653

High

508157

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.647

High

1248434

LRC46
Leucine-rich repeat-containing protein 46

4

20

High-throughput

0.630

High

957614

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

8

High-throughput

0.621

High

993623

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.621

High

927362

ATX1
Ataxin-1

2

1

High-throughput

0.620

High

1232895

XAF1
XIAP-associated factor 1

2

1

High-throughput

0.606

High

1248424

Q7KZS0
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.594

High

1248440

PHF23
PHD finger protein 23

2

0

Small-scale

0.593

High

1248443

ZMAT4
Zinc finger matrin-type protein 4

2

0

High-throughput

0.580

High

1248444

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

928481

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

899983

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.541

High

943589

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

4

High-throughput

0.541

High

1060530

KLC1
Kinesin light chain 1

1

2

High-throughput

0.541

High

1248422

RN111
E3 ubiquitin-protein ligase Arkadia

1

2

High-throughput

0.541

High

1248425

TRI74
Tripartite motif-containing protein 74

1

4

High-throughput

0.541

High

1248431

TSC1
Hamartin

1

10

High-throughput

0.541

High

1248442

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.541

High

1248453

NINL
Ninein-like protein

1

5

High-throughput

0.541

High

1248456

TRI17
E3 ubiquitin-protein ligase TRIM17

1

4

High-throughput

0.541

High

158657

TYB4Y
Thymosin beta-4, Y-chromosomal

1

1

High-throughput

0.536

High

906422

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.536

High

996479

ACTS
Actin, alpha skeletal muscle

1

7

High-throughput

0.536

High

1248421

MPRIP
Myosin phosphatase Rho-interacting protein

1

6

High-throughput

0.536

High

1248436

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

20

High-throughput

0.536

High

1248439

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

1

High-throughput

0.536

High

75512

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

7

High-throughput

0.528

High

1093646

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.518

High

873401

LSS
Lanosterol synthase

1

0

High-throughput

0.513

High

1248441

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

1248426

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

2

High-throughput

0.494

High

1248447

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

1

High-throughput

0.489

High

184720

ATX7
Ataxin-7

1

0

High-throughput

0.486

High

288441

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

High-throughput

0.481

High

1248445

GP108
Protein GPR108

1

1

High-throughput

0.481

High

1248451

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.481

High

126127

AP3B1
AP-3 complex subunit beta-1

1

1

Small-scale

0.479

High

363444

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.479

High

374698

RASH
GTPase HRas

1

15

High-throughput

0.479

High

461610

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

468513

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

1100844

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

Small-scale

0.479

High

1113459

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1248423

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1248432

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

1248446

KCNH7
Voltage-gated inwardly rectifying potassium channel KCNH7

1

3

High-throughput

0.470

High

848144

MAGA1
Melanoma-associated antigen 1

1

0

Small-scale

0.460

High

979014

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1248429

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

533995

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

17

High-throughput

0.457

High

873161

RXRG
Retinoic acid receptor RXR-gamma

1

11

High-throughput

0.457

High

1248435

Q96I30
GPR108 protein

1

1

High-throughput

0.457

High

775158

FUS
RNA-binding protein FUS

1

1

Small-scale

0.445

High

1119173

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1209295

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

19

High-throughput

0.445

High

1248428

NLS1
Sodium-dependent lysophosphatidylcholine symporter 1

1

1

High-throughput

0.445

High

1248430

DDX1
ATP-dependent RNA helicase DDX1

1

3

High-throughput

0.445

High

952213

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.438

High

372354

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

472320

CFAH
Complement factor H

1

2

Small-scale

0.437

High

1248437

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

164931

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.417

High

190402

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.407

High

1238875

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.407

High

450201

LIPF
Gastric triacylglycerol lipase

3

0

High-throughput

0.347

High

1248427

F178B
Protein FAM178B

1

0

High-throughput

0.282

High

1157439

GRIK5
Glutamate receptor ionotropic, kainate 5

1

0

High-throughput

0.238

Low

1248450

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.238

Low

1248452

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.238

Low

1248449

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025