HitPredict

Interactor 1: CSN1 (P45432)
COP9 signalosome complex subunit 1 (CSN complex subunit 1) (Constitutive photomorphogenesis protein 11) (Protein FUSCA 6)
Gene: CSN1

Interactor 2: CSN7 (Q94JU3)
COP9 signalosome complex subunit 7 (CSN complex subunit 7) (Protein FUSCA 5)
Gene: CSN7

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.946

Property	Details
Experiments	18854373, 10330469, 12615944, 21614643, 11742986, 23818606
Identification Methods	pull down, two hybrid, x-ray crystallography
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	PCI~PCI, PCI~RPN7
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0009585 - red, far-red light phototransduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 At			1 260
+	Mm
		102351 G3UXW9_MOUSE (28-440): 4.8e-105: 323: 45.64		CSN7B_MOUSE (1-255): 1.53e-78: 239: 32.56
+	Mm
		1207344 CSN1_MOUSE (28-440): 5.96e-104: 318: 45.64		CSN7B_MOUSE (1-255): 1.53e-78: 239: 32.56
+	Mm
		102353 G3UXW9_MOUSE (28-440): 4.8e-105: 323: 45.64		CSN7A_MOUSE (12-255): 1.71e-74: 229: 30.28
+	Hs
		1024222 CSN1_HUMAN (28-440): 1.81e-100: 310: 45.00		CSN7B_HUMAN (1-255): 1.99e-79: 241: 32.56
+	At
		1278364 PSD11_ARATH (18-431): 1.02e-82: 262: 13.04		CSN7_ARATH (1-260): 4.96e-98: 288: 100.00
+	Hs
		1024236 CSN1_HUMAN (28-440): 1.81e-100: 310: 45.00		CSN7A_HUMAN (12-255): 1.4e-75: 232: 30.28
+	Hs
		1062898 PSMD6_HUMAN (32-428): 2.95e-109: 329: 19.35		PSD13_HUMAN (16-191): 1.36e-54: 181: 17.20
+	Dm
		1277031 CSN2_DROME (61-427): 2.6e-81: 259: 15.34		CSN7_DROME (2-257): 6.25e-81: 246: 32.56
+	Hs
		897312 CSN2_HUMAN (62-427): 1.2e-75: 244: 14.85		CSN7B_HUMAN (1-255): 1.99e-79: 241: 32.56
+	Dm
		1180993 PSMD6_DROME (31-428): 1.38e-101: 309: 17.54		Q7KMP8_DROME (24-191): 1.43e-51: 174: 20.23
+	Hs
		897324 CSN2_HUMAN (62-427): 1.2e-75: 244: 14.85		CSN7A_HUMAN (12-255): 1.4e-75: 232: 30.28
+	Mm
		897342 CSN2_MOUSE (62-427): 1.2e-75: 244: 14.85		CSN7A_MOUSE (12-255): 1.71e-74: 229: 30.28
+	Hs
		121872 PSD11_HUMAN (67-429): 1.25e-80: 257: 14.56		PSD13_HUMAN (16-191): 1.36e-54: 181: 17.20
+	Sc
		978512 RPN6_YEAST (66-429): 1.84e-85: 270: 14.44		RPN9_YEAST (11-191): 1.48e-46: 161: 15.18
+	Dm
		1180705 PSD11_DROME (71-430): 2.51e-80: 256: 14.68		Q7KMP8_DROME (24-191): 1.43e-51: 174: 20.23
+	Sp
		1013799 RPN7_SCHPO (49-421): 2.61e-87: 273: 18.25		RPN9_SCHPO (15-189): 7.89e-43: 151: 17.55
+	Ce
		1276131 CSN1_CAEEL (13-440): 4.45e-80: 260: 24.69		EIF3M_CAEEL (2-216): 1.3e-44: 156: 19.73
+	Sc
		978500 RPN7_YEAST (54-421): 9.49e-77: 247: 19.33		RPN9_YEAST (11-191): 1.48e-46: 161: 15.18
+	Ce
		136315 CSN2_CAEEL (64-421): 4.05e-77: 250: 13.41		EIF3M_CAEEL (2-216): 1.3e-44: 156: 19.73
+	An
		961357 CSN2_EMENI (66-418): 3.18e-75: 245: 15.30		CSN7_EMENI (1-221): 8.33e-44: 152: 30.00