Protein: CPSF3
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)

Gene: CPSF3
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9UKF6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004521 - RNA endonuclease activity
GO:0004534 - 5'-3' RNA exonuclease activity
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1454617

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

5

14

Small-scale

0.932

High

1368775

SYMPK
Symplekin

5

8

Small-scale

0.716

High

340792

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

4

9

High-throughput

0.704

High

1083455

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

4

8

Small-scale

0.694

High

750494

CSTF2
Cleavage stimulation factor subunit 2

3

10

Small-scale

0.675

High

1248094

FIP1
Pre-mRNA 3'-end-processing factor FIP1

3

4

Small-scale

0.667

High

1421326

WDR33
pre-mRNA 3' end processing protein WDR33

3

10

Small-scale

0.662

High

1279925

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

5

Small-scale

0.647

High

373451

MYC
Myc proto-oncogene protein

3

4

High-throughput

0.640

High

66976

CPS4L
Putative cleavage and polyadenylation specificity factor subunit 4-like protein

2

9

High-throughput

0.628

High

1434917

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

1

Small-scale

0.628

High

667503

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

Small-scale

0.585

High

567110

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

2

2

High-throughput

0.574

High

1453168

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.555

High

436754

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

191418

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

2

High-throughput

0.536

High

447559

NPM
Nucleophosmin

1

1

Small-scale

0.536

High

1050314

CSTF1
Cleavage stimulation factor subunit 1

1

5

High-throughput

0.536

High

1092362

CSTF3
Cleavage stimulation factor subunit 3

1

3

High-throughput

0.536

High

1111346

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1145430

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.536

High

1160337

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

1240720

CDC73
Parafibromin

1

1

Small-scale

0.536

High

1310514

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1399784

RBM14
RNA-binding protein 14

1

2

High-throughput

0.536

High

1404491

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1430194

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

10

High-throughput

0.536

High

1445983

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

5

High-throughput

0.536

High

1461079

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.536

High

415925

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

656271

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

831625

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

844079

HD
Huntingtin

1

1

High-throughput

0.515

High

452433

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.513

High

682118

RBTN1
Rhombotin-1

1

0

High-throughput

0.513

High

1333175

KDM1B
Lysine-specific histone demethylase 2

1

0

High-throughput

0.513

High

1450782

KTU
Protein kintoun

1

0

High-throughput

0.513

High

1453462

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

899770

PAPOA
Poly(A) polymerase alpha

1

8

Small-scale

0.500

High

347402

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

1243068

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.489

High

1384152

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

129534

MEN1
Menin

1

2

High-throughput

0.479

High

260590

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

346473

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

406779

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

473168

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

11

High-throughput

0.479

High

538087

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

589998

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

657710

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

696825

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

731690

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

769478

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

879603

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

883361

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

905270

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

980517

H4
Histone H4

1

5

High-throughput

0.479

High

1029970

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.479

High

1067822

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1126846

SLBP
Histone RNA hairpin-binding protein

1

1

Small-scale

0.479

High

1127232

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1129783

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.479

High

1138155

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1257165

PAXI1
PAX-interacting protein 1

1

3

High-throughput

0.479

High

1339756

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1367549

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1380243

FBXW7
F-box/WD repeat-containing protein 7

1

2

Small-scale

0.479

High

1382857

FUBP1
Far upstream element-binding protein 1

1

3

High-throughput

0.479

High

1406801

BARD1
BRCA1-associated RING domain protein 1

1

1

High-throughput

0.479

High

1433862

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

2

High-throughput

0.479

High

1448238

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1449247

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1459254

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1461078

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

170418

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

248134

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

445613

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

552726

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

884419

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

1101088

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1107321

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1289704

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1352822

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1370456

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1371145

IRF7
Interferon regulatory factor 7

1

0

Small-scale

0.458

High

1429083

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

1429390

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1446544

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

430490

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

1147017

PCBP2
Poly(rC)-binding protein 2

1

3

Small-scale

0.445

High

1235014

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1460684

DDX41
Probable ATP-dependent RNA helicase DDX41

1

2

High-throughput

0.445

High

132369

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

243253

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.437

High

320133

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

412782

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

845360

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

High-throughput

0.437

High

971267

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1141013

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

1227674

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

1256030

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1276941

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1291005

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.437

High

1389419

RNF31
E3 ubiquitin-protein ligase RNF31

1

3

High-throughput

0.437

High

1397542

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1434194

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1198691

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1420757

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1437397

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1280111

UBE3D
E3 ubiquitin-protein ligase E3D

4

0

High-throughput

0.367

High

269473

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.279

Low

692151

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.279

Low

1146410

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.279

Low

1181449

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.279

Low

352801

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.251

Low

675199

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

959289

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

976648

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1126206

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1324198

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1326947

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1330437

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1393814

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1461080

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025