Protein: CPSF2
Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)

Gene: CPSF2
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q9P2I0

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0006398 - mRNA 3'-end processing by stem-loop binding and cleavage
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1454617

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

5

14

Small-scale

0.932

High

1368772

SYMPK
Symplekin

7

7

Small-scale

0.746

High

1248090

FIP1
Pre-mRNA 3'-end-processing factor FIP1

4

4

Small-scale

0.694

High

340787

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

3

9

High-throughput

0.667

High

1421323

WDR33
pre-mRNA 3' end processing protein WDR33

3

10

Small-scale

0.650

High

1083449

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

3

8

Small-scale

0.640

High

1145412

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.621

High

750490

CSTF2
Cleavage stimulation factor subunit 2

2

9

Small-scale

0.611

High

1114519

CUL3
Cullin-3

2

2

High-throughput

0.611

High

243175

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

980468

H4
Histone H4

2

3

High-throughput

0.584

High

1434915

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

1

Small-scale

0.584

High

373371

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.571

High

397118

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

1453159

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.555

High

191411

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

2

High-throughput

0.536

High

251667

CCNT1
Cyclin-T1

1

1

High-throughput

0.536

High

478240

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

480335

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

542261

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

775352

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

1111326

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1160329

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

1240711

CDC73
Parafibromin

1

1

Small-scale

0.536

High

1310485

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1399775

RBM14
RNA-binding protein 14

1

1

High-throughput

0.536

High

1404469

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1445981

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

4

High-throughput

0.536

High

889670

CLK2
Dual specificity protein kinase CLK2

1

0

High-throughput

0.513

High

902955

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.513

High

1417203

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

667492

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

Small-scale

0.501

High

964483

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

899769

PAPOA
Poly(A) polymerase alpha

1

8

Small-scale

0.500

High

1155849

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.493

High

1384142

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

129502

MEN1
Menin

1

2

High-throughput

0.479

High

132356

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

157943

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

260561

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

280853

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.479

High

316104

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

320110

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

331381

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

406753

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

447533

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

473152

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

11

High-throughput

0.479

High

487841

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

590505

GATA1
Erythroid transcription factor

1

1

High-throughput

0.479

High

657698

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

662664

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

1

High-throughput

0.479

High

755013

H2B1B
Histone H2B type 1-B

1

2

High-throughput

0.479

High

769393

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

831569

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

879563

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

905230

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

965299

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

986783

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1024902

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1092358

CSTF3
Cleavage stimulation factor subunit 3

1

3

Small-scale

0.479

High

1115470

CUL4B
Cullin-4B

1

2

High-throughput

0.479

High

1127214

RBM39
RNA-binding protein 39

1

2

High-throughput

0.479

High

1129769

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

1140972

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1227613

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

1279917

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

5

Small-scale

0.479

High

1339744

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1367474

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1371166

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

3

Small-scale

0.479

High

1382851

FUBP1
Far upstream element-binding protein 1

1

3

High-throughput

0.479

High

1397511

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1406795

BARD1
BRCA1-associated RING domain protein 1

1

1

High-throughput

0.479

High

1430189

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

9

Small-scale

0.479

High

1433854

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

1

High-throughput

0.479

High

1449235

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1454615

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1454619

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

218900

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

349275

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

485482

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.458

High

681538

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

1012274

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.458

High

1045859

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1133019

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1152663

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

1205103

FA76B
Protein FAM76B

1

0

High-throughput

0.458

High

1235552

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1346968

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1415892

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1430030

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

1436524

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

430452

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

1147010

PCBP2
Poly(rC)-binding protein 2

1

3

Small-scale

0.445

High

1454616

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

High-throughput

0.445

High

401625

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.437

High

412733

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1255903

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1276898

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1389407

RNF31
E3 ubiquitin-protein ligase RNF31

1

3

High-throughput

0.437

High

1434110

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1436815

WDR76
WD repeat-containing protein 76

1

4

High-throughput

0.437

High

1454614

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

1454618

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

1401895

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1091363

FOXL1
Forkhead box protein L1

1

0

High-throughput

0.279

Low

1434860

ASB7
Ankyrin repeat and SOCS box protein 7

1

0

High-throughput

0.279

Low

1437184

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

0

High-throughput

0.251

Low

272520

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

294460

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1242429

RHGBA
Rho GTPase-activating protein 11A

1

0

High-throughput

0.249

Low

1253673

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.249

Low

1351181

SP7
Transcription factor Sp7

1

0

High-throughput

0.249

Low

1360129

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

1132455

CASP8
Caspase-8

1

0

High-throughput

0.232

Low

1396585

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025