HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	16729043, 22973453
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016477 - cell migration and 1 others more... GO:0031594 - neuromuscular junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 1308
+	Hs
		601844 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383684 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		383685 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338101 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338102 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Mm
		337631 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		ABL1_MOUSE (693-1305): 6.8e-128: 424: 24.32
+	Hs
		337388 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Mm
		337621 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		ABL1_MOUSE (693-1305): 6.8e-128: 424: 24.32
+	Hs
		665560 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Hs
		337389 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		802571 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		789043 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		802577 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		665378 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		EPHA3_HUMAN (705-987): 6.17e-54: 207: 39.10
+	Mm
		796508 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		ZAP70_MOUSE (724-967): 2.11e-55: 206: 42.45
+	Hs
		796460 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ZAP70_HUMAN (724-967): 1.42e-54: 204: 41.63
+	Mm
		796493 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		ZAP70_MOUSE (724-967): 2.11e-55: 206: 42.45
+	Hs
		411331 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		435576 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11
+	Hs
		411332 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05