HitPredict

Interactor 1: BRCC3 (P46736)
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
Gene: BRCC3

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

The method score is based on:

Property	Details
Experiments	17525341, 17664283, 14636569
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000152 - nuclear ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 6 others more... GO:0006282 - regulation of DNA repair GO:0044818 - mitotic G2/M transition checkpoint GO:0046872 - metal ion binding GO:0070531 - BRCA1-A complex GO:0071479 - cellular response to ionizing radiation GO:2000001 - regulation of DNA damage checkpoint
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	316
Hs

1	777

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024