HitPredict

Interactor 1: SMC2 (P38989)
Structural maintenance of chromosomes protein 2 (DA-box protein SMC2)
Gene: SMC2

Interactor 2: SCC1 (Q12158)
Sister chromatid cohesion protein 1
Gene: MCD1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37486771
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0007076 - mitotic chromosome condensation GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1170 Sc			1 566
+	Sc
		747766 SMC1_YEAST (2-1170): 4.34e-72: 264: 16.33		SCC1_YEAST (1-566): 0: 543: 100.00
+	Hs
		238332 SMC2_HUMAN (1-1167): 8.59e-104: 357: 35.75		RAD21_HUMAN (14-560): 2.57e-147: 440: 15.72
+	Hs
		238623 SMC4_HUMAN (1-1170): 2.7e-90: 319: 16.32		RAD21_HUMAN (14-560): 2.57e-147: 440: 15.72
+	Xl
		313485 SMC3_XENLA (1-1170): 2.04e-77: 280: 17.40		RAD21_XENLA (14-560): 6e-150: 446: 15.92
+	Xl
		1231397 Q8AW91_XENLA (1-1170): 1.01e-76: 278: 17.36		Q6DCL7_XENLA (14-560): 7.78e-150: 446: 15.61
+	Xl
		313494 Q8AW91_XENLA (1-1170): 1.01e-76: 278: 17.36		RAD21_XENLA (14-560): 6e-150: 446: 15.92
+	Hs
		238641 SMC3_HUMAN (1-1170): 1.95e-75: 274: 17.61		RAD21_HUMAN (14-560): 2.57e-147: 440: 15.72
+	Hs
		238520 SMC1A_HUMAN (2-1170): 3.69e-74: 271: 15.84		RAD21_HUMAN (14-560): 2.57e-147: 440: 15.72
+	Mm
		1223005 SMC3_MOUSE (1-1170): 1.61e-75: 275: 17.61		RAD21_MOUSE (14-560): 1.25e-144: 433: 16.08
+	Xl
		313474 SMC1A_XENLA (2-1170): 2.76e-70: 259: 15.35		RAD21_XENLA (14-560): 6e-150: 446: 15.92
+	Mm
		1223004 SMC1A_MOUSE (2-1170): 2.42e-74: 271: 15.76		RAD21_MOUSE (14-560): 1.25e-144: 433: 16.08
+	Mm
		59830 SMC3_MOUSE (1-1170): 1.61e-75: 275: 17.61		RD21L_MOUSE (14-561): 3.48e-143: 426: 15.49
+	Mm
		59829 SMC1A_MOUSE (2-1170): 2.42e-74: 271: 15.76		RD21L_MOUSE (14-561): 3.48e-143: 426: 15.49
+	Hs
		238565 SMC1B_HUMAN (2-1170): 2.59e-69: 256: 16.83		RAD21_HUMAN (14-560): 2.57e-147: 440: 15.72
+	Mm
		1298089 SMC3_MOUSE (1-1170): 1.61e-75: 275: 17.61		REC8_MOUSE (18-559): 2.04e-105: 330: 13.09
+	Dm
		355904 Q9VXE9_DROME (1-1170): 2.07e-75: 274: 19.74		O96689_DROME (14-523): 2.09e-98: 316: 15.95
+	Hs
		326169 SMC3_HUMAN (1-1170): 1.95e-75: 274: 17.61		REC8_HUMAN (18-560): 6.22e-98: 309: 14.39
+	Hs
		326147 SMC1A_HUMAN (2-1170): 3.69e-74: 271: 15.84		REC8_HUMAN (18-560): 6.22e-98: 309: 14.39
+	Dm
		355900 Q9VCD8_DROME (2-1170): 4.14e-72: 264: 17.13		O96689_DROME (14-523): 2.09e-98: 316: 15.95
+	Hs
		326155 SMC1B_HUMAN (2-1170): 2.59e-69: 256: 16.83		REC8_HUMAN (18-560): 6.22e-98: 309: 14.39