Protein: SMC1
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)

Gene: SMC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: P32908

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000217 - DNA secondary structure binding
GO:0003677 - DNA binding
GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

747737

SMC3
Structural maintenance of chromosomes protein 3

24

18

Small-scale

0.992

High

747766

SCC1
Sister chromatid cohesion protein 1

26

20

Small-scale

0.991

High

747756

SCC2
Sister chromatid cohesion protein 2

6

7

Small-scale

0.939

High

747711

SMC1
Structural maintenance of chromosomes protein 1

2

18

Small-scale

0.781

High

747767

REC8
Meiotic recombination protein REC8

2

1

Small-scale

0.754

High

747731

SCC3
Cohesin subunit SCC3

8

20

Small-scale

0.746

High

739938

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

3

10

Small-scale

0.675

High

747757

PDS5
Sister chromatid cohesion protein PDS5

3

20

Small-scale

0.674

High

555242

RAD50
DNA repair protein RAD50

1

17

High-throughput

0.656

High

747722

SMC2
Structural maintenance of chromosomes protein 2

1

18

High-throughput

0.656

High

747728

SCC4
MAU2 chromatid cohesion factor homolog

3

1

Small-scale

0.640

High

637194

PWP1
Periodic tryptophan protein 1

2

3

High-throughput

0.621

High

747769

SMC4
Structural maintenance of chromosomes protein 4

1

18

Small-scale

0.618

High

747773

SMC6
Structural maintenance of chromosomes protein 6

1

19

High-throughput

0.618

High

523465

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.611

High

594280

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

3

High-throughput

0.584

High

677670

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

747749

TOF1
Topoisomerase 1-associated factor 1

1

1

Small-scale

0.561

High

526269

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

678861

CSM1
Monopolin complex subunit CSM1

2

1

Small-scale

0.539

High

544292

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.536

High

747723

END3
Actin cytoskeleton-regulatory complex protein END3

2

3

High-throughput

0.526

High

704888

KIP2
Kinesin-like protein KIP2

1

3

High-throughput

0.515

High

747739

ARP3
Actin-related protein 3

1

3

High-throughput

0.515

High

747748

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.515

High

488598

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

602037

KAR3
Kinesin-like protein KAR3

1

4

High-throughput

0.508

High

747715

NUF2
Kinetochore protein NUF2

1

4

High-throughput

0.508

High

747717

DYHC
Dynein heavy chain, cytoplasmic

1

1

High-throughput

0.508

High

747735

MAD1
Spindle assembly checkpoint component MAD1

1

14

High-throughput

0.508

High

747741

NNF1
Kinetochore-associated protein NNF1

1

1

High-throughput

0.508

High

747762

BRE1
E3 ubiquitin-protein ligase BRE1

1

13

High-throughput

0.508

High

747759

CSM3
Chromosome segregation in meiosis protein 3

1

1

Small-scale

0.501

High

747770

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.500

High

678830

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.493

High

747718

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.486

High

747734

MET28
Transcriptional activator of sulfur metabolism MET28

1

0

High-throughput

0.486

High

747755

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.486

High

747758

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.486

High

642028

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

Small-scale

0.481

High

649541

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.480

High

626670

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

434961

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

706622

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

709337

HRR25
Casein kinase I homolog HRR25

1

8

Small-scale

0.479

High

709656

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

743069

STH1
Nuclear protein STH1/NPS1

1

6

Small-scale

0.479

High

747712

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

747716

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

747719

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

747720

INCE
Inner centromere protein SLI15

1

1

Small-scale

0.479

High

747725

RSP5
E3 ubiquitin-protein ligase RSP5

1

4

Small-scale

0.479

High

747733

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

747752

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

747764

SGO1
Shugoshin

1

3

High-throughput

0.479

High

747753

COFI
Cofilin

1

1

High-throughput

0.470

High

747746

NNF2
Protein NNF2

1

1

High-throughput

0.464

High

747747

YG3A
Uncharacterized protein YGR130C

1

10

High-throughput

0.464

High

483764

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.460

High

642173

OPI1
Transcriptional repressor OPI1

1

0

High-throughput

0.460

High

747760

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.460

High

747768

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

747772

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

381040

H2B1
Histone H2B.1

1

12

High-throughput

0.445

High

392472

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

481560

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

675852

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

741252

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

742807

HSP79
Heat shock protein homolog SSE2

1

16

High-throughput

0.445

High

747713

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

747721

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

747726

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

747729

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

747738

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

747740

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.445

High

747744

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.445

High

433543

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

435867

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

454963

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

512342

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

512909

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

674514

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

747254

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

747714

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

747724

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

747743

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

747754

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

747763

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

747765

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

653843

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

577073

SEC63
Protein translocation protein SEC63

1

3

High-throughput

0.407

High

747732

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.407

High

747736

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

747751

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

747761

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

747771

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

739576

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.269

Low

747745

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

410025

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

441807

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

747727

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

747730

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

747742

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

747750

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025