HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: PTN21 (Q16825)
Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)
Gene: PTPN21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27432908, 30472188
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1174
+	Hs
		1087931 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		PTN21_HUMAN (1-1174): 0: 888: 100.00
+	Hs
		125485 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PTN14_HUMAN (3-1174): 0: 813: 52.54
+	Hs
		1076918 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		PTN14_HUMAN (3-1174): 0: 813: 52.54
+	Hs
		808641 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PTN14_HUMAN (3-1174): 0: 813: 52.54
+	Hs
		1076917 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		PTN14_HUMAN (3-1174): 0: 813: 52.54
+	Dm
		1359218 SUDX_DROME (16-504): 4.46e-109: 347: 15.74		Q9V3V3_DROME (1-1174): 3.31e-151: 488: 23.33
+	Hs
		1336123 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		E41L3_HUMAN (15-899): 2.79e-124: 411: 16.94
+	Hs
		204630 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		E41L2_HUMAN (7-542): 3.43e-125: 411: 23.99
+	Hs
		505580 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		EPB41_HUMAN (2-564): 6.62e-114: 377: 21.58
+	Hs
		547209 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		EZRI_HUMAN (19-552): 2.91e-115: 372: 17.06
+	Hs
		640152 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		MOES_HUMAN (20-329): 2.54e-114: 369: 25.79
+	Hs
		546968 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		EZRI_HUMAN (19-552): 2.91e-115: 372: 17.06
+	Hs
		546967 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		EZRI_HUMAN (19-552): 2.91e-115: 372: 17.06
+	Hs
		505678 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		EPB41_HUMAN (2-564): 6.62e-114: 377: 21.58
+	Hs
		547208 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		EZRI_HUMAN (19-552): 2.91e-115: 372: 17.06
+	Mm
		719315 ITCH_MOUSE (2-504): 2.6e-119: 372: 14.36		PTN11_MOUSE (920-1170): 2.54e-37: 151: 36.50
+	Hs
		808559 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PTN13_HUMAN (27-316): 2.37e-17: 90.5: 28.39
+	Hs
		986030 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		PTN11_HUMAN (920-1170): 2.14e-37: 151: 35.36
+	Hs
		616920 MAGI3_HUMAN (69-270): 5.85e-40: 156: 21.64		PTPRB_HUMAN (899-1173): 1.56e-37: 156: 36.17
+	Hs
		1020213 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		PTN13_HUMAN (27-316): 2.37e-17: 90.5: 28.39