HitPredict

Interactor 1: KCNJ1 (P48048)
ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)
Gene: KCNJ1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	14604981
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Hs			1 337
+	Hs
		153896 KCNJ1_HUMAN (1-391): 0: 610: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Mm
		291382 KCNJ1_MOUSE (20-391): 0: 574: 92.74		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		929762 KCNJ2_HUMAN (35-390): 0: 551: 45.40		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Rn
		1144360 KCNJ2_RAT (35-390): 0: 549: 45.13		DLG2_RAT (79-232): 1.42e-14: 76.5: 18.63
+	Hs
		929764 KCNJ2_HUMAN (35-390): 0: 551: 45.40		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		929767 KCNJ2_HUMAN (35-390): 0: 551: 45.40		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Rn
		1144015 KCNJ2_RAT (35-390): 0: 549: 45.13		DLG1_RAT (87-232): 1.5e-13: 73.5: 18.30
+	Hs
		1054723 KCJ12_HUMAN (35-388): 0: 538: 45.63		DLG2_HUMAN (79-232): 1.39e-14: 76.5: 18.63
+	Hs
		942342 KCJ12_HUMAN (35-388): 0: 538: 45.63		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1021490 KCJ12_HUMAN (35-388): 0: 538: 45.63		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1049947 KCJ12_HUMAN (35-388): 0: 538: 45.63		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Rn
		852400 KCJ12_RAT (35-388): 0: 534: 45.63		DLG2_RAT (79-232): 1.42e-14: 76.5: 18.63
+	Rn
		677769 KCJ12_RAT (35-388): 0: 534: 45.63		DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48
+	Rn
		852397 KCJ12_RAT (35-388): 0: 534: 45.63		DLG1_RAT (87-232): 1.5e-13: 73.5: 18.30
+	Hs
		80982 KCJ18_HUMAN (35-388): 0: 533: 45.35		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1054724 KCJ12_HUMAN (35-388): 0: 538: 45.63		DLG3_HUMAN (89-220): 8.62e-10: 61.9: 17.99
+	Hs
		1054728 KCJ12_HUMAN (35-388): 0: 538: 45.63		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Rn
		852399 KCJ12_RAT (35-388): 0: 534: 45.63		DLG3_RAT (103-220): 4.99e-09: 59.6: 20.00
+	Rn
		852401 KCJ12_RAT (35-388): 0: 534: 45.63		LIN7C_RAT (9-87): 8.5e-09: 56.6: 40.74
+	Hs
		816159 KCNJ6_HUMAN (36-369): 0: 512: 45.81		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31