HitPredict

Interactor 1: CXA8 (P48165)
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)
Gene: GJA8

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12808044
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 1748
+	Hs
		990963 CXA3_HUMAN (1-433): 0: 535: 44.37		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		567025 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Mm
		613304 CXA1_MOUSE (1-343): 9.46e-123: 363: 39.77		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Rn
		94331 CXA1_RAT (1-343): 9.46e-123: 363: 39.77		F1M4A0_RAT (27-1748): 0: 866: 90.88
+	Mm
		761849 CXB6_MOUSE (3-238): 5.17e-117: 344: 49.37		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Hs
		990884 CXD3_HUMAN (1-238): 1.26e-95: 290: 40.34		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		159154 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		567101 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		567033 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Rn
		435339 CXA1_RAT (1-343): 9.46e-123: 363: 39.77		Q3ZB99_RAT (1086-1374): 1.62e-20: 101: 20.00
+	Hs
		661171 CXB2_HUMAN (3-240): 4.54e-123: 358: 51.46		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		567187 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		567035 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		306903 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		UNC5C_HUMAN (1635-1728): 1.98e-13: 77.8: 47.37
+	Hs
		567162 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71
+	Mm
		222439 CXD2_MOUSE (1-265): 5.77e-117: 346: 38.10		ZO2_MOUSE (172-572): 2.71e-15: 84.2: 16.94
+	Hs
		567315 CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		434831 CXB1_HUMAN (3-290): 8.02e-111: 329: 40.61		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		1021517 CXB7_HUMAN (4-243): 1.42e-106: 315: 43.80		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		306919 CXD3_HUMAN (1-238): 1.26e-95: 290: 40.34		UNC5C_HUMAN (1635-1728): 1.98e-13: 77.8: 47.37