HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28794006, 35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035019 - somatic stem cell population maintenance
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 1233
+	Mm
		818762 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMC1A_MOUSE (1-1233): 1.34e-128: 427: 99.84
+	Hs
		1057362 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		311503 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57
+	Hs
		818618 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Mm
		818763 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMC3_MOUSE (3-1229): 1.17e-70: 261: 16.00
+	Hs
		1301004 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00